دورية أكاديمية
Drug release rates from four sizes of a new transdermal nitroglycerin adhesive patch.
| العنوان: | Drug release rates from four sizes of a new transdermal nitroglycerin adhesive patch. |
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| المؤلفون: | Riedel DJ; 3M Riker, 3M Health Care Group, St. Paul, Minnesota., Wick KA, Hawkinson RW, Kolars CA, Crowley JK, Harrison LI, de Dennis SR |
| المصدر: | Clinical therapeutics [Clin Ther] 1989 May-Jun; Vol. 11 (3), pp. 409-16. |
| نوع المنشور: | Clinical Trial; Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Excerpta Medica Country of Publication: United States NLM ID: 7706726 Publication Model: Print Cited Medium: Print ISSN: 0149-2918 (Print) Linking ISSN: 01492918 NLM ISO Abbreviation: Clin Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Belle Mead, NJ, : Excerpta Medica Original Publication: Princeton, N. J., Excerpta Medica. |
| مواضيع طبية MeSH: | Nitroglycerin/*administration & dosage, Administration, Cutaneous ; Adolescent ; Adult ; Humans ; Male ; Nitroglycerin/adverse effects ; Skin/drug effects |
| مستخلص: | This study was conducted to determine the amount of nitroglycerin released from transdermal nitroglycerin patches of four different sizes: 3.3 cm2, 6.7 cm2, 13.3 cm2, and 20 cm2. Thirty healthy men received a single 24-hour application of each patch size according to a randomized, open-label, four-period crossover design. A 24-hour interval separated each treatment period. The total amount of nitroglycerin released by the four patches was proportional to size. All four patch sizes released nitroglycerin at a comparable rate. The mean overall 24-hour release rate of 0.76 mg/cm2 was similar to the release rate of 0.75 mg/cm2/24 hr observed in a previous study. Adverse experiences common to nitroglycerin administration were reported for all patch sizes, with headache, light-headedness, and nausea reported most frequently. |
| المشرفين على المادة: | G59M7S0WS3 (Nitroglycerin) |
| تواريخ الأحداث: | Date Created: 19890501 Date Completed: 19890815 Latest Revision: 20131121 |
| رمز التحديث: | 20240627 |
| PMID: | 2501032 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0149-2918 |
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