دورية أكاديمية
Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula.
| العنوان: | Subdomain-mediated axon-axon signaling and chemoattraction cooperate to regulate afferent innervation of the lateral habenula. |
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| المؤلفون: | Schmidt ERE; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Brignani S; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Adolfs Y; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Lemstra S; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Demmers J; Proteomics Centre and Department of Cell Biology, Erasmus University Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, the Netherlands., Vidaki M; Department of Basic Science, Faculty of Medicine, University of Crete and Institute of Molecular Biology and Biotechnology, Vassilika Vouton, Heraklion GR-7110, Greece., Donahoo AS; Queensland Brain Institute and The School of Biomedical Sciences, University of Queensland, Building 79, St Lucia Campus, Brisbane, QLD 4067, Australia., Lilleväli K; Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, 50411 Tartu, Estonia., Vasar E; Department of Physiology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, 50411 Tartu, Estonia., Richards LJ; Queensland Brain Institute and The School of Biomedical Sciences, University of Queensland, Building 79, St Lucia Campus, Brisbane, QLD 4067, Australia., Karagogeos D; Department of Basic Science, Faculty of Medicine, University of Crete and Institute of Molecular Biology and Biotechnology, Vassilika Vouton, Heraklion GR-7110, Greece., Kolk SM; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands., Pasterkamp RJ; Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands. Electronic address: r.j.pasterkamp@umcutrecht.nl. |
| المصدر: | Neuron [Neuron] 2014 Jul 16; Vol. 83 (2), pp. 372-387. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, Mass. : Cell Press, c1988- |
| مواضيع طبية MeSH: | Axons/*metabolism , Chemotaxis/*physiology , Habenula/*physiology , Lysosomal Membrane Proteins/*metabolism , Neurons, Afferent/*physiology, Animals ; Chemotactic Factors/metabolism ; Dopaminergic Neurons/physiology ; Mice ; Mice, Knockout ; Nerve Growth Factors/genetics ; Nerve Growth Factors/metabolism ; Netrin-1 ; Neural Pathways/physiology ; Synapses/physiology ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism |
| مستخلص: | A dominant feature of neural circuitry is the organization of neuronal projections and synapses into specific brain nuclei or laminae. Lamina-specific connectivity is controlled by the selective expression of extracellular guidance and adhesion molecules in the target field. However, how (sub)nucleus-specific connections are established and whether axon-derived cues contribute to subdomain targeting are largely unknown. Here, we demonstrate that the lateral subnucleus of the habenula (lHb) determines its own afferent innervation by sending out efferent projections that express the cell adhesion molecule LAMP to reciprocally collect and guide dopaminergic afferents to the lHb-a phenomenon we term subdomain-mediated axon-axon signaling. This process of reciprocal axon-axon interactions cooperates with lHb-specific chemoattraction mediated by Netrin-1, which controls axon target entry, to ensure specific innervation of the lHb. We propose that cooperation between pretarget reciprocal axon-axon signaling and subdomain-restricted instructive cues provides a highly precise and general mechanism to establish subdomain-specific neural circuitry. (Copyright © 2014 Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Chemotactic Factors) 0 (Lysosomal Membrane Proteins) 0 (Nerve Growth Factors) 0 (Ntn1 protein, mouse) 0 (Tumor Suppressor Proteins) 158651-98-0 (Netrin-1) |
| تواريخ الأحداث: | Date Created: 20140718 Date Completed: 20140912 Latest Revision: 20231213 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.neuron.2014.05.036 |
| PMID: | 25033181 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-4199 |
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| DOI: | 10.1016/j.neuron.2014.05.036 |