دورية أكاديمية
[Comparative characteristics of genetic aberrations in glioblastomas in children and adults].
| العنوان: | [Comparative characteristics of genetic aberrations in glioblastomas in children and adults]. |
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| المؤلفون: | Ryzhova MV, Shishkina LV, Zheludkova OG, Golanov AV, Gorelyshev SK, Pitskhelauri DI, Bekiashev AKh, Kobiakov GL, Absaliamova OV, Sycheva RV, Korshunov AG |
| المصدر: | Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko [Zh Vopr Neirokhir Im N N Burdenko] 2014; Vol. 78 (2), pp. 3-11; discussion 11. |
| نوع المنشور: | Comparative Study; English Abstract; Journal Article |
| اللغة: | English; Russian |
| بيانات الدورية: | Publisher: Media Sfera Country of Publication: Russia (Federation) NLM ID: 7809757 Publication Model: Print Cited Medium: Print ISSN: 0042-8817 (Print) Linking ISSN: 00428817 NLM ISO Abbreviation: Zh Vopr Neirokhir Im N N Burdenko Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Media Sfera Original Publication: Moskva, Meditsina. |
| مواضيع طبية MeSH: | Chromosome Aberrations*, Glioblastoma/*genetics , Glioblastoma/*pathology , Neoplasm Proteins/*genetics, Adolescent ; Adult ; Child ; Child, Preschool ; Humans ; Male ; Middle Aged |
| مستخلص: | Glioblastomas in children and adults are a heterogeneous group of tumors that can be divided into at least three different subgroups: pediatric glioblastomas, IDH1-mutant glioblastomas in adults (the most favorable prognostic subtype), and IDH1-wild type glioblastomas in adults. According to the frequency of detected cytogenetic aberrations (amplification of the MYC/MYCN, EGFR and PDGRFA oncogenes, homozygous deletion of the CDKN2A gene, and deletion of the PTEN gene), pediatric glioblastomas bear analogy to the subgroup of IDH1-mutant glioblastomas in adults. |
| المشرفين على المادة: | 0 (Neoplasm Proteins) |
| تواريخ الأحداث: | Date Created: 20140719 Date Completed: 20140818 Latest Revision: 20180404 |
| رمز التحديث: | 20240628 |
| PMID: | 25033601 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0042-8817 |
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