دورية أكاديمية
Preoperative chemotherapy prior to pulmonary metastasectomy in surgically resected primary colorectal carcinoma.
| العنوان: | Preoperative chemotherapy prior to pulmonary metastasectomy in surgically resected primary colorectal carcinoma. |
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| المؤلفون: | Subbiah IM; Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Blackmon SH; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Surgery, The Methodist Hospital and Weill Cornell College of Medicine, Houston, Texas., Correa AM; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kee B; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Vaporciyan AA; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Swisher SG; Department of Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Eng C; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. |
| المصدر: | Oncotarget [Oncotarget] 2014 Aug 30; Vol. 5 (16), pp. 6584-93. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, N.Y. : Impact Journals |
| مواضيع طبية MeSH: | Antineoplastic Combined Chemotherapy Protocols/*administration & dosage , Colorectal Neoplasms/*drug therapy , Colorectal Neoplasms/*surgery , Lung Neoplasms/*drug therapy , Lung Neoplasms/*surgery , Metastasectomy/*methods, Camptothecin/administration & dosage ; Camptothecin/analogs & derivatives ; Capecitabine ; Chemotherapy, Adjuvant ; Colorectal Neoplasms/pathology ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/analogs & derivatives ; Humans ; Irinotecan ; Lung Neoplasms/secondary ; Male ; Middle Aged ; Neoadjuvant Therapy ; Organoplatinum Compounds/administration & dosage ; Oxaliplatin ; Preoperative Care/methods ; Prospective Studies ; Survival Rate |
| مستخلص: | Background: The benefit of preoperative chemotherapy prior to pulmonary metastasectomy for patients with colorectal carcinoma (CRC) is unknown. Here, we identify outcomes of preoperative chemotherapy in patients with resected primary CRC who then underwent pulmonary metastasectomy. Methods: We queried a prospective database to identify treatment characteristics. Multivariate analyses identified predictors of overall survival (OS) and progression-free survival (PFS). Results: 229 patients underwent lung metastasectomy, of whom 115 proceeded to surgery without chemotherapy while 114 received preoperative regimen based on oxaliplatin (32%), irinotecan (46%), capecitabine (16%), or other (6%). Median PFS in preoperative chemotherapy vs. surgery alone arms were comparable (p=0.004). Patients on oxaliplatin-based therapy had an improved OS vs. an irinotecan, capecitabine, or alternate regimen (p=.019). On multivariate analysis, the irinotecan subset had a worse OS (HR 1.846; 95% CI 1.070, 3.185) vs. surgery alone arm (p=0.028). The OS of an oxaliplatin-based regimen vs. no chemotherapy was inconclusive (HR 0.57; 95% CI 0.237 to 1.389, p=0.218). Multivariate analysis demonstrated a worse PFS and OS for the male gender and an incomplete resection (R2). Conclusion: Prospective trials on specific preoperative regimens and criteria for patient selection may identify a role for preoperative chemotherapy prior to a curative pulmonary metastasectomy. |
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| معلومات مُعتمدة: | P30 CA016672 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Organoplatinum Compounds) 04ZR38536J (Oxaliplatin) 0W860991D6 (Deoxycytidine) 6804DJ8Z9U (Capecitabine) 7673326042 (Irinotecan) U3P01618RT (Fluorouracil) XT3Z54Z28A (Camptothecin) |
| تواريخ الأحداث: | Date Created: 20140723 Date Completed: 20150603 Latest Revision: 20221109 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4196147 |
| DOI: | 10.18632/oncotarget.2172 |
| PMID: | 25051371 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1949-2553 |
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| DOI: | 10.18632/oncotarget.2172 |