دورية أكاديمية
أعرض في EDS

The geographic distribution of onchocerciasis in the 20 participating countries of the African Programme for Onchocerciasis Control: (2) pre-control endemicity levels and estimated number infected.

التفاصيل البيبلوغرافية
العنوان: The geographic distribution of onchocerciasis in the 20 participating countries of the African Programme for Onchocerciasis Control: (2) pre-control endemicity levels and estimated number infected.
المؤلفون: Zouré HG, Noma M, Tekle AH, Amazigo UV, Diggle PJ, Giorgi E, Remme JH; Consultant, 120 Rue des Campanules, Ornex 01210, France. hansremme@gmail.com.
المصدر: Parasites & vectors [Parasit Vectors] 2014 Jul 22; Vol. 7, pp. 326. Date of Electronic Publication: 2014 Jul 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305 (Electronic) Linking ISSN: 17563305 NLM ISO Abbreviation: Parasit Vectors Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مواضيع طبية MeSH: Filaricides/*therapeutic use , Ivermectin/*therapeutic use , Onchocerciasis/*drug therapy , Onchocerciasis/*epidemiology, Africa/epidemiology ; Animals ; Diptera ; Disease Vectors ; Endemic Diseases ; Epidemiologic Methods ; Humans ; Prevalence
مستخلص: Background: The original aim of the African Programme for Onchocerciasis Control (APOC) was to control onchocerciasis as a public health problem in 20 African countries. In order to identify all high risk areas where ivermectin treatment was needed to achieve control, APOC used Rapid Epidemiological Mapping of Onchocerciasis (REMO). REMO involved spatial sampling of villages to be surveyed, and examination of 30 to 50 adults per village for palpable onchocercal nodules. REMO has now been virtually completed and we report the results in two articles. A companion article reports the delineation of high risk areas based on expert analysis. The present article reports the results of a geostatistical analysis of the REMO data to map endemicity levels and estimate the number infected.
Methods: A model-based geostatistical analysis of the REMO data was undertaken to generate high-resolution maps of the predicted prevalence of nodules and of the probability that the true nodule prevalence exceeds the high risk threshold of 20%. The number infected was estimated by converting nodule prevalence to microfilaria prevalence, and multiplying the predicted prevalence for each location with local data on population density. The geostatistical analysis included the nodule palpation data for 14,473 surveyed villages.
Results: The generated map of onchocerciasis endemicity levels, as reflected in the prevalence of nodules, is a significant advance with many new endemic areas identified. The prevalence of nodules was > 20% over an area of 2.5 million km2 with an estimated population of 62 million people. The results were consistent with the delineation of high risk areas of the expert analysis except for borderline areas where the prevalence fluctuated around 20%. It is estimated that 36 million people would have been infected in the APOC countries by 2011 if there had been no ivermectin treatment.
Conclusions: The map of onchocerciasis endemicity levels has proven very valuable for onchocerciasis control in the APOC countries. Following the recent shift to onchocerciasis elimination, the map continues to play an important role in planning treatment, evaluating impact and predicting treatment end dates in relation to local endemicity levels.
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معلومات مُعتمدة: G0902153 United Kingdom MRC_ Medical Research Council
المشرفين على المادة: 0 (Filaricides)
70288-86-7 (Ivermectin)
تواريخ الأحداث: Date Created: 20140724 Date Completed: 20150309 Latest Revision: 20220409
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4222889
DOI: 10.1186/1756-3305-7-326
PMID: 25053392
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-3305
DOI:10.1186/1756-3305-7-326