دورية أكاديمية
Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation.
| العنوان: | Urethral dysfunction due to alloxan-induced diabetes. Urodynamic and morphological evaluation. |
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| المؤلفون: | Pegorare AB; Department of Surgery and Anatomy, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil., Gonçalves MA; Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil., Suaid CA; Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil., Rodrigues Junior AA; Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil., Tucci S Jr; Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil., Suaid HJ; Department of Surgery and Anatomy, FMRP, USP, Ribeirao Preto, SP, Brazil. |
| المصدر: | Acta cirurgica brasileira [Acta Cir Bras] 2014 Jul; Vol. 29 (7), pp. 457-64. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Country of Publication: Brazil NLM ID: 9103983 Publication Model: Print Cited Medium: Internet ISSN: 1678-2674 (Electronic) Linking ISSN: 01028650 NLM ISO Abbreviation: Acta Cir Bras Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sao Paulo : Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Original Publication: São Paulo : A Sociedade, |
| مواضيع طبية MeSH: | Diabetes Mellitus, Experimental/*complications , Diabetes Mellitus, Experimental/*physiopathology , Urethra/*physiopathology , Urinary Bladder/*physiopathology , Urodynamics/*physiology, Alloxan ; Animals ; Collagen/analysis ; Female ; Muscle Contraction/physiology ; Muscle, Smooth/physiopathology ; Pressure ; Rats, Wistar ; Time Factors ; Urethra/pathology ; Urethral Diseases/etiology ; Urethral Diseases/pathology ; Urethral Diseases/physiopathology ; Urinary Bladder/pathology |
| مستخلص: | Purpose: To evaluate the effect of short and long term alloxan-induced diabetes on bladder and urethral function of female rats, and also describing its correlated morphological alterations. Methods: Thirty five female rats were divided into three groups: G1 (n=9), control group; G2 (n=17), six weeks alloxan-induced diabetic rats; G3 (n=9), 20 weeks alloxan-induced diabetic rats. Functional evaluation was performed by cystometry and simultaneous measurements of the urethral pressure during bladder filling and voiding. Morphological evaluation was also performed with measurement of bladder and urethral fibrosis and collagen content and thickness of lamina propria and smooth muscle layers. Results: The peak bladder pressures and contraction amplitudes were decreased in 100% and 47% of the G3 and G2 groups respectively, when compared to control. Bladder overactivity was observed in 53% of the G2 group. Conclusion: Alloxan-induced diabetes urethropathty in female rat was associated to bladder morphological alterations as higher thicknesses of it lamina propria, detrusor and adventicea. |
| المشرفين على المادة: | 6SW5YHA5NG (Alloxan) 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20140724 Date Completed: 20150406 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1590/s0102-86502014000700008 |
| PMID: | 25054877 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1678-2674 |
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| DOI: | 10.1590/s0102-86502014000700008 |