دورية أكاديمية
Extreme pain from brown recluse spider bites: model for cytokine-driven pain.
| العنوان: | Extreme pain from brown recluse spider bites: model for cytokine-driven pain. |
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| المؤلفون: | Payne KS; Stoecker & Associates, Rolla, Missouri., Schilli K; Stoecker & Associates, Rolla, Missouri., Meier K; Stoecker & Associates, Rolla, Missouri., Rader RK; Stoecker & Associates, Rolla, Missouri2University of Missouri School of Medicine, Columbia., Dyer JA; Department of Dermatology, University of Missouri School of Medicine, Columbia., Mold JW; Department of Family and Preventive Medicine, University of Oklahoma Health Sciences Center, Oklahoma City., Green JA; Division of Animal Sciences, University of Missouri, Columbia., Stoecker WV; Stoecker & Associates, Rolla, Missouri3Department of Dermatology, University of Missouri School of Medicine, Columbia. |
| المصدر: | JAMA dermatology [JAMA Dermatol] 2014 Nov; Vol. 150 (11), pp. 1205-8. |
| نوع المنشور: | Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101589530 Publication Model: Print Cited Medium: Internet ISSN: 2168-6084 (Electronic) Linking ISSN: 21686068 NLM ISO Abbreviation: JAMA Dermatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago, IL : American Medical Association, [2013]- |
| مواضيع طبية MeSH: | Brown Recluse Spider*, Cytokines/*metabolism , Pain/*etiology , Spider Bites/*complications, Animals ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Inflammation Mediators/metabolism ; Neuroglia/metabolism ; Pain Measurement ; Spider Bites/pathology ; Time Factors ; Young Adult |
| مستخلص: | Importance: Bites from the brown recluse spider (BRS) can cause extreme pain. We propose cytokine release as a cause of the discomfort and a central mechanism through glial cell upregulation to explain measured pain levels and time course. Observations: Twenty-three BRS bites were scored at a probable or documented level clinically, and an enzyme-linked immunosorbent assay was used to confirm the presence of BRS venom. The mean (SD) pain level in these cases 24 hours after the spider bite was severe: 6.74 (2.75) on a scale of 0 to 10. Narcotics may be needed to provide relief in some cases. The difference in pain level by anatomic region was not significant. Escalation observed in 22 of 23 cases, increasing from low/none to extreme within 24 hours, is consistent with a cytokine pain pattern, in which pain increases concomitantly with a temporal increase of inflammatory cytokines. Conclusions and Relevance: These findings in BRS bites support the hypothesis of cytokine release in inflammatory pain. A larger series is needed to confirm the findings reported here. The extreme pain from many BRS bites motivates us to find better prevention and treatment techniques. |
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| معلومات مُعتمدة: | R43 AR055863 United States AR NIAMS NIH HHS; R44 AR055863 United States AR NIAMS NIH HHS; R44 AR055863-02 United States AR NIAMS NIH HHS; R43 AR055863-01 United States AR NIAMS NIH HHS |
| المشرفين على المادة: | 0 (Cytokines) 0 (Inflammation Mediators) |
| تواريخ الأحداث: | Date Created: 20140731 Date Completed: 20150120 Latest Revision: 20211021 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4229416 |
| DOI: | 10.1001/jamadermatol.2014.605 |
| PMID: | 25076008 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2168-6084 |
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| DOI: | 10.1001/jamadermatol.2014.605 |