دورية أكاديمية
Evaluation of intraosseous pressure in a hypovolemic animal model.
| العنوان: | Evaluation of intraosseous pressure in a hypovolemic animal model. |
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| المؤلفون: | Frascone RJ; Department of Emergency Medicine, Regions Hospital, St. Paul, MN., Salzman JG; Critical Care Reseach Center, Regions Hospital, St. Paul, MN. Electronic address: Joshua.g.salzman@healthpartners.com., Adams AB; HealthPartners Institute for Education and Research, Bloomington, MN., Bliss P; Home Healthcare Solutions, Philips Healthcare, Kennesaw, GA., Wewerka SS; Critical Care Reseach Center, Regions Hospital, St. Paul, MN., Dries DJ; Department of Surgical Services, HealthPartners Medical Group, Bloomington, MN; Department of Surgery, University of Minnesota, Minneapolis, Minnesota. |
| المصدر: | The Journal of surgical research [J Surg Res] 2015 Jan; Vol. 193 (1), pp. 383-90. Date of Electronic Publication: 2014 Jul 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0376340 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8673 (Electronic) Linking ISSN: 00224804 NLM ISO Abbreviation: J Surg Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Academic Press Original Publication: Philadelphia [etc.] |
| مواضيع طبية MeSH: | Catheterization, Central Venous* , Disease Models, Animal* , Sus scrofa* , Vascular Access Devices*, Hypovolemia/*physiopathology , Shock, Hemorrhagic/*physiopathology, Animals ; Aorta ; Blood Pressure/physiology ; Female ; Femoral Artery ; Femoral Vein ; Hypovolemia/therapy ; Infusions, Intraosseous ; Pressure ; Resuscitation/methods ; Shock, Hemorrhagic/therapy ; Vena Cava, Superior |
| مستخلص: | Background: In emergent situations, access to the vascular bed is frequently required for fluid and medication administration. Central venous catheter placement is associated with risk and may slow resuscitation in the unstable patient. The purpose of this study was to determine whether intraosseous pressure (IOP) could be consistently recorded and how similar this pressure was to central venous and arterial pressure in a porcine hemorrhagic shock model. Materials and Methods: After sedation, eight female swine had catheters placed in the femoral vein, aorta via femoral artery, and superior vena cava. IOP lines were placed in the proximal humerus, distal femur, and proximal tibia. Pressure readings were recorded continuously through the five stages of progressive hypovolemia. Pressure data were descriptively summarized, with the percent of change of IOP at each stage compared with arterial pressure using a multilevel mixed effects linear model with log transformation. Results: The IOP baseline values were between 16 and 18 mm Hg, approximately 22% of baseline arterial pressure. The intraosseous (IO) waveform mostly closely resembled the arterial pressure waveform, including the presence of a dichroitic notch. Pressure variations caused by ventilation (respiratory variability) were also identified in all the tracings. The rate of pressure change in the humeral IO most closely matched the change in arterial pressure rate. IO blood gas analysis showed gas composition to most closely match venous blood. Conclusions: IOP was reliably obtained in this porcine model and suggests potential for clinical application in humans. (Copyright © 2015 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Blood pressure; Central venous catheter; Hemorrhage; Intraosseous; Shock |
| تواريخ الأحداث: | Date Created: 20140806 Date Completed: 20150316 Latest Revision: 20220321 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jss.2014.07.007 |
| PMID: | 25091338 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1095-8673 |
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| DOI: | 10.1016/j.jss.2014.07.007 |