دورية أكاديمية
أعرض في EDS

Emerging roles for the FCRL family members in lymphocyte biology and disease.

التفاصيل البيبلوغرافية
العنوان: Emerging roles for the FCRL family members in lymphocyte biology and disease.
المؤلفون: Li FJ; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Won WJ, Becker EJ Jr, Easlick JL, Tabengwa EM, Li R, Shakhmatov M, Honjo K, Burrows PD, Davis RS
المصدر: Current topics in microbiology and immunology [Curr Top Microbiol Immunol] 2014; Vol. 382, pp. 29-50.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0110513 Publication Model: Print Cited Medium: Print ISSN: 0070-217X (Print) Linking ISSN: 0070217X NLM ISO Abbreviation: Curr Top Microbiol Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Heidelberg : Springer Verlag
مواضيع طبية MeSH: B-Lymphocytes/*physiology , Receptors, Fc/*physiology, Animals ; Humans ; Ligands ; Receptors, Fc/analysis ; Signal Transduction/physiology
مستخلص: Members of the extended Fc receptor-like (FCRL) family in humans and mice are preferentially expressed by B cells and possess tyrosine-based immunoregulatory function. Although the majority of these proteins repress B cell receptor-mediated activation, there is an emerging evidence for their bifunctionality and capacity to counter-regulate adaptive and innate signaling pathways. In light of these findings, the recent discovery of ligands for several of these molecules has begun to reveal exciting potential for them in normal lymphocyte biology and is launching a new phase of FCRL investigation. Importantly, these fundamental developments are also setting the stage for defining their altered roles in the pathogenesis of a growing number of immune-mediated diseases. Here we review recent advances in the FCRL field and highlight the significance of these intriguing receptors in normal and perturbed immunobiology.
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معلومات مُعتمدة: P30 AI027767 United States AI NIAID NIH HHS; R21 AI097729 United States AI NIAID NIH HHS; AI027767 United States AI NIAID NIH HHS; CA175912 United States CA NCI NIH HHS; AI100076 United States AI NIAID NIH HHS; CA161731 United States CA NCI NIH HHS; R33 CA161731 United States CA NCI NIH HHS; R21 CA175912 United States CA NCI NIH HHS; AI097729 United States AI NIAID NIH HHS; R03 AI100076 United States AI NIAID NIH HHS
المشرفين على المادة: 0 (FCRLA protein, human)
0 (Ligands)
0 (Receptors, Fc)
تواريخ الأحداث: Date Created: 20140814 Date Completed: 20141117 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4242170
DOI: 10.1007/978-3-319-07911-0_2
PMID: 25116094
قاعدة البيانات: MEDLINE
الوصف
تدمد:0070-217X
DOI:10.1007/978-3-319-07911-0_2