دورية أكاديمية
أعرض في EDS

Incidence, risk factors, and outcomes of delayed graft function in deceased donor kidney transplantation in a Brazilian center.

التفاصيل البيبلوغرافية
العنوان: Incidence, risk factors, and outcomes of delayed graft function in deceased donor kidney transplantation in a Brazilian center.
المؤلفون: Helfer MS; School of Medicine, Federal University of Rio Grande do Sul, Brazil., Vicari AR; Division of Nephrology, Renal Transplant Unit, Hospital de Clínicas de Porto Alegre, Brazil., Spuldaro F; Division of Nephrology, Renal Transplant Unit, Hospital de Clínicas de Porto Alegre, Brazil., Gonçalves LF; School of Medicine, Federal University of Rio Grande do Sul, Brazil; Division of Nephrology, Renal Transplant Unit, Hospital de Clínicas de Porto Alegre, Brazil., Manfro RC; School of Medicine, Federal University of Rio Grande do Sul, Brazil; Division of Nephrology, Renal Transplant Unit, Hospital de Clínicas de Porto Alegre, Brazil. Electronic address: rmanfro@hcpa.ufrgs.br.
المصدر: Transplantation proceedings [Transplant Proc] 2014 Jul-Aug; Vol. 46 (6), pp. 1727-9.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Inc Country of Publication: United States NLM ID: 0243532 Publication Model: Print Cited Medium: Internet ISSN: 1873-2623 (Electronic) Linking ISSN: 00411345 NLM ISO Abbreviation: Transplant Proc Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, N.Y. : Elsevier Science Inc.
Original Publication: New York Stratton.
مواضيع طبية MeSH: Delayed Graft Function/*etiology , Kidney Transplantation/*adverse effects, Adult ; Age Factors ; Antibodies, Monoclonal/therapeutic use ; Brazil ; Cohort Studies ; Creatinine/blood ; Female ; Humans ; Immunosuppression Therapy ; Incidence ; Length of Stay ; Logistic Models ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Tissue Donors
مستخلص: Background: A high incidence of delayed graft function (DGF) after deceased donor kidney transplantation occurs in Brazil. The reasons for such have not been adequately studied.
Methods: We performed a retrospective cohort study of 346 kidney transplant recipients from deceased donors. DGF risk factors related to the recipient, donor, and transplantation surgery were analyzed and correlated with graft outcomes. A logistic regression analysis was used to identify independent risk factors and patient and graft survival were assessed using Kaplan-Meier curves.
Results: The incidence of DGF was 70.8% (245 cases). Our final model of multivariate analysis showed that DGF is associated (P < .05) with donor final serum creatinine (relative risk [RR], 1.84; 95% confidence interval [CI], 1.26-2.70), donor age (RR, 1.02 [1.0-1.033]), receiving a kidney from national offer (RR, 2.44 [1.06-5.59]), and need for antibody induction (RR, 2.87 [1.33-6.18]). Outcomes that were associated with DGF were longer length of hospital stay (32.5 ± 20.5 vs 18.8 ± 16.3 days; P = .01), higher incidence of acute rejection (37.8 vs 12.9%; P < .01), worse graft survival at 1 year (83.5% vs 93.9%; P < .01), and higher levels of serum creatinine at 3, 6, and 12 months (P < .05). There was no difference in patient survival and the occurrence of acute rejection did not influence the survival of patients or grafts.
Conclusion: DGF was associated with higher donor final serum creatinine, donor age, receiving a kidney from the national supply, and need for antibody induction. Most importantly, DGF was associated with worse outcomes.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
المشرفين على المادة: 0 (Antibodies, Monoclonal)
AYI8EX34EU (Creatinine)
تواريخ الأحداث: Date Created: 20140819 Date Completed: 20150909 Latest Revision: 20220318
رمز التحديث: 20221213
DOI: 10.1016/j.transproceed.2014.05.026
PMID: 25131022
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2623
DOI:10.1016/j.transproceed.2014.05.026