دورية أكاديمية
KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand.
العنوان: | KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand. |
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المؤلفون: | Nemat-Gorgani N; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA., Edinur HA, Hollenbach JA, Traherne JA, Dunn PP, Chambers GK, Parham P, Norman PJ |
المصدر: | Immunogenetics [Immunogenetics] 2014 Nov; Vol. 66 (11), pp. 597-611. Date of Electronic Publication: 2014 Aug 21. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Verlag Country of Publication: United States NLM ID: 0420404 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1211 (Electronic) Linking ISSN: 00937711 NLM ISO Abbreviation: Immunogenetics Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New York, NY : Springer Verlag, |
مواضيع طبية MeSH: | HLA-B Antigens/*genetics , Native Hawaiian or Other Pacific Islander/*genetics , Population/*genetics , Receptors, KIR/*genetics, Alleles ; Haplotypes/genetics ; Humans ; New Zealand ; Polynesia |
مستخلص: | HLA class I molecules and killer cell immunoglobulin-like receptors (KIR) form a diverse system of ligands and receptors that individualize human immune systems in ways that improve the survival of individuals and populations. Human settlement of Oceania by island-hopping East and Southeast Asian migrants started ~3,500 years ago. Subsequently, New Zealand was reached ~750 years ago by ancestral Māori. To examine how this history impacted KIR and HLA diversity, and their functional interaction, we defined at high resolution the allelic and haplotype diversity of the 13 expressed KIR genes in 49 Māori and 34 Polynesians. Eighty KIR variants, including four 'new' alleles, were defined, as were 35 centromeric and 22 telomeric KIR region haplotypes, which combine to give >50 full-length KIR haplotypes. Two new and divergent variant KIR form part of a telomeric KIR haplotype, which appears derived from Papua New Guinea and was probably obtained by the Asian migrants en route to Polynesia. Māori and Polynesian KIR are very similar, but differ significantly from African, European, Japanese, and Amerindian KIR. Māori and Polynesians have high KIR haplotype diversity with corresponding allotype diversity being maintained throughout the KIR locus. Within the population, each individual has a unique combination of HLA class I and KIR. Characterizing Māori and Polynesians is a paucity of HLA-B allotypes recognized by KIR. Compensating for this deficiency are high frequencies (>50 %) of HLA-A allotypes recognized by KIR. These HLA-A allotypes are ones that modern humans likely acquired from archaic humans at a much earlier time. |
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معلومات مُعتمدة: | R01 AI017892 United States AI NIAID NIH HHS; GM109030 United States GM NIGMS NIH HHS; United Kingdom MRC_ Medical Research Council; R01 GM109030 United States GM NIGMS NIH HHS; AI17892 United States AI NIAID NIH HHS |
المشرفين على المادة: | 0 (HLA-B Antigens) 0 (Receptors, KIR) |
تواريخ الأحداث: | Date Created: 20140821 Date Completed: 20141211 Latest Revision: 20211203 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC4198482 |
DOI: | 10.1007/s00251-014-0794-1 |
PMID: | 25139336 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1432-1211 |
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DOI: | 10.1007/s00251-014-0794-1 |