دورية أكاديمية
Temporal and region-specific requirements of αCaMKII in spatial and contextual learning.
| العنوان: | Temporal and region-specific requirements of αCaMKII in spatial and contextual learning. |
|---|---|
| المؤلفون: | Achterberg KG; Department of Psychiatry., Buitendijk GH; Department of Neuroscience, and., Kool MJ; Department of Neuroscience, and ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands, and., Goorden SM; Department of Neuroscience, and ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands, and., Post L; Department of Neuroscience, and., Slump DE; Department of Psychiatry., Silva AJ; Departments of Neurobiology, Psychiatry, Psychology, and Brain Research Institute, University of California, Los Angeles, California 90095., van Woerden GM; Department of Neuroscience, and ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands, and., Kushner SA; Department of Psychiatry, s.kushner@erasmusmc.nl y.elgersma@erasmusmc.nl., Elgersma Y; Department of Neuroscience, and ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands, and s.kushner@erasmusmc.nl y.elgersma@erasmusmc.nl. |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2014 Aug 20; Vol. 34 (34), pp. 11180-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism , Conditioning, Classical/*physiology , Fear/*physiology , Maze Learning/*physiology , Spatial Behavior/*physiology, Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Conditioning, Classical/drug effects ; Estrogen Antagonists/pharmacology ; Excitatory Postsynaptic Potentials/genetics ; Fear/drug effects ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Hippocampus/cytology ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Integrases/genetics ; Integrases/metabolism ; Long-Term Potentiation/genetics ; Maze Learning/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Neurons/drug effects ; Neurons/physiology ; Patch-Clamp Techniques ; Spatial Behavior/drug effects ; Tamoxifen/pharmacology ; Transcription Factors/genetics ; Transcription Factors/metabolism |
| مستخلص: | The α isoform of the calcium/calmodulin-dependent protein kinase II (αCaMKII) has been implicated extensively in molecular and cellular mechanisms underlying spatial and contextual learning in a wide variety of species. Germline deletion of Camk2a leads to severe deficits in spatial and contextual learning in mice. However, the temporal and region-specific requirements for αCaMKII have remained largely unexplored. Here, we generated conditional Camk2a mutants to examine the influence of spatially restricted and temporally controlled expression of αCaMKII. Forebrain-specific deletion of the Camk2a gene resulted in severe deficits in water maze and contextual fear learning, whereas mice with deletion restricted to the cerebellum learned normally. Furthermore, we found that temporally controlled deletion of the Camk2a gene in adult mice is as detrimental as germline deletion for learning and synaptic plasticity. Together, we confirm the requirement for αCaMKII in the forebrain, but not the cerebellum, in spatial and contextual learning. Moreover, we highlight the absolute requirement for intact αCaMKII expression at the time of learning. (Copyright © 2014 the authors 0270-6474/14/3411180-08$15.00/0.) |
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| معلومات مُعتمدة: | R37 AG013622 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: CaMKII; cerebellum; fear conditioning; hippocampus; learning; spatial learning |
| المشرفين على المادة: | 0 (Estrogen Antagonists) 0 (Homeodomain Proteins) 0 (Nerve Tissue Proteins) 0 (Purkinje cell protein L7) 0 (Transcription Factors) 0 (empty spiracles homeobox proteins) 094ZI81Y45 (Tamoxifen) EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2) EC 2.7.11.17 (Camk2a protein, mouse) EC 2.7.7.- (Cre recombinase) EC 2.7.7.- (Integrases) |
| تواريخ الأحداث: | Date Created: 20140822 Date Completed: 20141222 Latest Revision: 20211021 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4340969 |
| DOI: | 10.1523/JNEUROSCI.0640-14.2014 |
| PMID: | 25143599 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-2401 |
|---|---|
| DOI: | 10.1523/JNEUROSCI.0640-14.2014 |