دورية أكاديمية
أعرض في EDS

Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: results of the Surgical Treatment for Ischemic Heart Failure trial.

التفاصيل البيبلوغرافية
العنوان: Myocardial viability and impact of surgical ventricular reconstruction on outcomes of patients with severe left ventricular dysfunction undergoing coronary artery bypass surgery: results of the Surgical Treatment for Ischemic Heart Failure trial.
المؤلفون: Holly TA; Northwestern University, Chicago, Ill. Electronic address: t-holly@northwestern.edu., Bonow RO; Northwestern University, Chicago, Ill., Arnold JM; University of Western Ontario, London, Ontario, Canada., Oh JK; Mayo Clinic, Rochester, Minn., Varadarajan P; Loma Linda University, Loma Linda, Calif., Pohost GM; University of Southern California, Los Angeles, Calif., Haddad H; Ottawa Heart Institute, Ottawa, Ontario, Canada., Jones RH; Duke University, Durham, NC., Velazquez EJ; Duke University, Durham, NC., Birkenfeld B; Department of Nuclear Medicine PUM, Szczecin, Poland., Asch FM; MedStar Washington Hospital Center, Washington, DC., Malinowski M; Medical University of Silesia, Katowice, Poland., Barretto R; Instituto Dante Pazzanese de Cardiologia, Sao Paulo, Brazil., Kalil RA; Instituto de Cardiologia, Porto Alegre, Brazil., Berman DS; Cedars-Sinai Medical Center, Los Angeles, Calif., Sun JL; Duke University, Durham, NC., Lee KL; Duke University, Durham, NC., Panza JA; Westchester Medical Center, Valhalla, NY.
المصدر: The Journal of thoracic and cardiovascular surgery [J Thorac Cardiovasc Surg] 2014 Dec; Vol. 148 (6), pp. 2677-84.e1. Date of Electronic Publication: 2014 Jul 30.
نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 0376343 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-685X (Electronic) Linking ISSN: 00225223 NLM ISO Abbreviation: J Thorac Cardiovasc Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: St. Louis, MO : Mosby
Original Publication: St. Louis.
مواضيع طبية MeSH: Coronary Artery Bypass*/adverse effects , Coronary Artery Bypass*/mortality , Plastic Surgery Procedures*/adverse effects , Plastic Surgery Procedures*/mortality , Ventricular Function, Left*, Cardiomyopathies/*surgery , Coronary Artery Disease/*surgery , Heart Failure/*surgery , Myocardium/*pathology , Ventricular Dysfunction, Left/*surgery, Aged ; Cardiomyopathies/diagnosis ; Cardiomyopathies/mortality ; Cardiomyopathies/physiopathology ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/mortality ; Coronary Artery Disease/physiopathology ; Female ; Heart Failure/diagnosis ; Heart Failure/physiopathology ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Predictive Value of Tests ; Proportional Hazards Models ; Severity of Illness Index ; Time Factors ; Tissue Survival ; Tomography, Emission-Computed, Single-Photon ; Treatment Outcome ; Ventricular Dysfunction, Left/diagnosis ; Ventricular Dysfunction, Left/mortality ; Ventricular Dysfunction, Left/physiopathology
مستخلص: Objectives: In the Surgical Treatment for Ischemic Heart Failure trial, surgical ventricular reconstruction plus coronary artery bypass surgery was not associated with a reduction in the rate of death or cardiac hospitalization compared with bypass alone. We hypothesized that the absence of viable myocardium identifies patients with coronary artery disease and left ventricular dysfunction who have a greater benefit with coronary artery bypass graft surgery and surgical ventricular reconstruction compared with bypass alone.
Methods: Myocardial viability was assessed by single photon computed tomography in 267 of the 1000 patients randomized to bypass or bypass plus surgical ventricular reconstruction in the Surgical Treatment for Ischemic Heart Failure. Myocardial viability was assessed on a per patient basis and regionally according to prespecified criteria.
Results: At 3 years, there was no difference in mortality or the combined outcome of death or cardiac hospitalization between those with and without viability, and there was no significant interaction between the type of surgery and the global viability status with respect to mortality or death plus cardiac hospitalization. Furthermore, there was no difference in mortality or death plus cardiac hospitalization between those with and without anterior wall or apical scar, and no significant interaction between the presence of scar in these regions and the type of surgery with respect to mortality.
Conclusions: In patients with coronary artery disease and severe regional left ventricular dysfunction, assessment of myocardial viability does not identify patients who will derive a mortality benefit from adding surgical ventricular reconstruction to coronary artery bypass graft surgery.
(Copyright © 2014 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.)
التعليقات: Comment in: J Thorac Cardiovasc Surg. 2014 Dec;148(6):2684-5. (PMID: 25451502)
Comment in: J Thorac Cardiovasc Surg. 2015 Jun;149(6):1682-3. (PMID: 26060012)
Comment in: J Thorac Cardiovasc Surg. 2015 Jun;149(6):1683-4. (PMID: 26060013)
References: Circulation. 1993 May;87(5):1630-41. (PMID: 8491019)
J Thorac Cardiovasc Surg. 2009 Nov;138(5):1060-1064.e2. (PMID: 19837213)
J Am Coll Cardiol. 2010 Aug 3;56(6):490-8. (PMID: 20670760)
J Am Coll Cardiol. 1993 Nov 1;22(5):1455-64. (PMID: 8227805)
N Engl J Med. 2011 Apr 28;364(17):1607-16. (PMID: 21463150)
N Engl J Med. 2009 Apr 23;360(17):1705-17. (PMID: 19329820)
J Heart Lung Transplant. 2010 May;29(5):491-6. (PMID: 20382350)
N Engl J Med. 2011 Apr 28;364(17):1617-25. (PMID: 21463153)
Circulation. 1993 Jan;87(1):1-20. (PMID: 8418996)
Circulation. 2002 Jan 29;105(4):539-42. (PMID: 11815441)
J Thorac Cardiovasc Surg. 2007 Dec;134(6):1540-7. (PMID: 18023680)
J Am Coll Cardiol. 2004 Oct 6;44(7):1439-45. (PMID: 15464325)
J Am Coll Cardiol. 1997 Aug;30(2):384-91. (PMID: 9247509)
معلومات مُعتمدة: U01 HL069013 United States HL NHLBI NIH HHS; U01 HL069012 United States HL NHLBI NIH HHS; R01 HL105853 United States HL NHLBI NIH HHS; UO1HL69013 United States HL NHLBI NIH HHS; U01 HL069015 United States HL NHLBI NIH HHS; U01HL69015 United States HL NHLBI NIH HHS; R01HL69012 United States HL NHLBI NIH HHS
تواريخ الأحداث: Date Created: 20140826 Date Completed: 20150123 Latest Revision: 20221207
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4250319
DOI: 10.1016/j.jtcvs.2014.06.090
PMID: 25152476
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-685X
DOI:10.1016/j.jtcvs.2014.06.090