دورية أكاديمية
Does adjuvant chemoradiotherapy improve the prognosis of gastric cancer after an r1 resection? Results from a dutch cohort study.
| العنوان: | Does adjuvant chemoradiotherapy improve the prognosis of gastric cancer after an r1 resection? Results from a dutch cohort study. |
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| المؤلفون: | Stiekema J; Department of Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Trip AK, Jansen EP, Aarts MJ, Boot H, Cats A, Ponz OB, Gradowska PL, Verheij M, van Sandick JW |
| المصدر: | Annals of surgical oncology [Ann Surg Oncol] 2015 Feb; Vol. 22 (2), pp. 581-8. Date of Electronic Publication: 2014 Aug 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Original Publication: New York, NY : Raven Press, c1994- |
| مواضيع طبية MeSH: | Chemoradiotherapy, Adjuvant*, Adenocarcinoma/*therapy , Stomach Neoplasms/*therapy, Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Aged ; Cohort Studies ; Female ; Gastrectomy/methods ; Humans ; Male ; Middle Aged ; Prognosis ; Registries ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Survival Analysis |
| مستخلص: | Objective: The aim of this study was to investigate the impact of adjuvant chemoradiotherapy (CRT) on survival of non-metastatic gastric cancer patients who had undergone an R1 resection. Methods: We compared the survival of patients after an R1 gastric cancer resection from the population-based Netherlands Cancer Registry who did not receive adjuvant CRT (no-CRT group) with the survival of resected patients who had been treated with adjuvant CRT (CRT group) at our institute. Patients who had a resection between 2002 and 2011 were included. CRT consisted of radiotherapy (45 Gy) combined with concurrent cisplatin- or 5-fluorouracil-based chemotherapy. The impact of CRT treatment on overall survival was assessed using multivariable Cox regression and stratified propensity score analysis. Results: A series of 409 gastric cancer patients who had undergone an R1 resection were studied (no-CRT, N = 369; CRT, N = 40). In the no-CRT group, median age was higher (70 vs. 57 years; p < 0.001) and the percentage of patients with diffuse-type tumors was lower (43 vs. 80 %; p < 0.001). There were no significant differences in pathological T- and N-classification. There was a significant difference in median overall survival between the no-CRT and CRT group (13 vs. 24 months; p = 0.003). In a multivariable analysis, adjuvant CRT was an independent prognostic factor for improved overall survival (hazard ratio 0.54; 95 % confidence interval 0.35-0.84). This effect of CRT was further supported by propensity score analysis. Conclusions: Adjuvant CRT was associated with an improved survival in patients who had undergone an R1 resection for gastric cancer. |
| تواريخ الأحداث: | Date Created: 20140829 Date Completed: 20150922 Latest Revision: 20150115 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1245/s10434-014-4032-8 |
| PMID: | 25164039 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1534-4681 |
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| DOI: | 10.1245/s10434-014-4032-8 |