دورية أكاديمية
أعرض في EDS

Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years.

التفاصيل البيبلوغرافية
العنوان: Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years.
المؤلفون: Tan le V; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam., Thai le H; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Phu NH; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Nghia HD; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam., Chuong LV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Sinh DX; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Phong ND; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Mai NT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Man DN; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Hien VM; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Vinh NT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Day J; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Chau NV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Hien TT; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Farrar J; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., de Jong MD; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Department of Medical Microbiology, Academic Medical, Center, University of Amsterdam, Amsterdam, The Netherlands., Thwaites G; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., van Doorn HR; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Chau TT; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2014 Aug 28; Vol. 8 (8), pp. e3127. Date of Electronic Publication: 2014 Aug 28 (Print Publication: 2014).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Central Nervous System Infections*/epidemiology , Central Nervous System Infections*/mortality , Central Nervous System Infections*/virology, Tertiary Care Centers/*statistics & numerical data , Viruses/*isolation & purification, Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Prospective Studies ; Vietnam/epidemiology ; Young Adult
مستخلص: Background: Central nervous system (CNS) infections are important diseases in both children and adults worldwide. The spectrum of infections is broad, encompassing bacterial/aseptic meningitis and encephalitis. Viruses are regarded as the most common causes of encephalitis and aseptic meningitis. Better understanding of the viral causes of the diseases is of public health importance, in order to better inform immunization policy, and may influence clinical management.
Methodology/principal Findings: Study was conducted at the Hospital for Tropical Diseases in Ho Chi Minh City, a primary, secondary, and tertiary referral hospital for all southern provinces of Vietnam. Between December 1996 and May 2008, patients with CNS infections of presumed viral origin were enrolled. Laboratory diagnostics consisted of molecular and serological tests targeted at 14 meningitis/encephalitis-associated viruses. Of 291 enrolled patients, fatal outcome and neurological sequelae were recorded in 10% (28/291) and 27% (78/291), respectively. Mortality was especially high (9/19, 47%) amongst those with confirmed herpes simplex encephalitis which is attributed to the limited availability of intravenous acyclovir/valacyclovir. Japanese encephalitis virus, dengue virus, herpes simplex virus, and enteroviruses were the most common viruses detected, responsible for 36 (12%), 19 (6.5%), 19 (6.5%) and 8 (2.7%) respectively, followed by rubella virus (6, 2%), varicella zoster virus (5, 1.7%), mumps virus (2, 0.7%), cytomegalovirus (1, 0.3%), and rabies virus (1, 0.3%).
Conclusions/significance: Viral infections of the CNS in adults in Vietnam are associated with high morbidity and mortality. Despite extensive laboratory testing, 68% of the patients remain undiagnosed. Together with our previous reports, the data confirm that Japanese encephalitis virus, dengue virus, herpes simplex virus, and enteroviruses are the leading identified causes of CNS viral infections in Vietnam, suggest that the majority of morbidity/mortality amongst patients with a confirmed/probable diagnosis is preventable by adequate vaccination/treatment, and are therefore of public health significance.
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معلومات مُعتمدة: United Kingdom Wellcome Trust; 101104 United Kingdom Wellcome Trust; G1100684 United Kingdom MRC_ Medical Research Council
تواريخ الأحداث: Date Created: 20140829 Date Completed: 20160111 Latest Revision: 20220310
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4148224
DOI: 10.1371/journal.pntd.0003127
PMID: 25165820
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0003127