دورية أكاديمية
Incidentally detected diffuse signal alterations of bone marrow on MRI: is bone marrow biopsy indicated?
| العنوان: | Incidentally detected diffuse signal alterations of bone marrow on MRI: is bone marrow biopsy indicated? |
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| المؤلفون: | Spierings J; Departments of Internal Medicine÷Haematology, Maxima Medical Centre, Eindhoven÷Veldhoven, the Netherlands., van der Linden AN, Kuijper PH, Tick LW, Nijziel MR |
| المصدر: | The Netherlands journal of medicine [Neth J Med] 2014 Sep; Vol. 72 (7), pp. 345-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Van Zuiden Communications Country of Publication: Netherlands NLM ID: 0356133 Publication Model: Print Cited Medium: Internet ISSN: 1872-9061 (Electronic) Linking ISSN: 03002977 NLM ISO Abbreviation: Neth J Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Alphen aan de Rijn, The Netherlands : Van Zuiden Communications Original Publication: Haarlem, Bohn |
| مواضيع طبية MeSH: | Biopsy* , Incidental Findings* , Magnetic Resonance Imaging*, Bone Marrow/*pathology , Hematologic Diseases/*pathology, Adult ; Aged ; Female ; Hematologic Diseases/diagnosis ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Young Adult |
| مستخلص: | Background: Advanced imaging techniques as magnetic resonance imaging (MRI) are increasingly performed in the diagnostic workup of patients. Incidentally, diffuse signal alterations of the bone marrow are detected because MRI visualises various components of the bone marrow. The clinical significance of these signal alterations is unknown. Objective: The main goal of this study was to determine the diagnostic value of a bone marrow biopsy in patients with incidentally found diffuse signal alterations of the bone marrow. Methods: We retrospectively examined all bone marrow biopsies performed from 1 January 2007 to 31 December 2013 (n = 1947). Patients were included when the biopsy was obtained following an MRI with a diffuse abnormal bone marrow signal. Patients who underwent MRI for suspected malignancy were excluded. Histological and cytological results of the bone marrow examinations were analysed. Results: 15 of the 1947 bone marrow biopsies (0.77%) were performed because of diffuse signal alterations on MRI. In seven of these 15 bone marrow biopsies (47%) a clinically important haematological disorder was found. Eight patients had a normal bone marrow evaluation. Conclusion: Based on this retrospective study, a bone marrow examination in patients with incidentally detected diffuse signal alterations should be considered to exclude haematological pathology. Prospective studies have to be performed to further investigate the best diagnostic strategy. |
| تواريخ الأحداث: | Date Created: 20140903 Date Completed: 20160525 Latest Revision: 20140902 |
| رمز التحديث: | 20221213 |
| PMID: | 25178767 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1872-9061 |
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