دورية أكاديمية
Combined effect of N-stearoyiletanolamine and ionizing radiation on hematological indices of peripheral blood in rats.
| العنوان: | Combined effect of N-stearoyiletanolamine and ionizing radiation on hematological indices of peripheral blood in rats. |
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| المؤلفون: | Rodionova NK, Atamaniuk NP, Derevyanko LP, Tal'ko VV, Yanina AM, Shelkovskiy MV, Kosyakova GV, Mehed OP, Gula NM, Chumak AA |
| المصدر: | Problemy radiatsiinoi medytsyny ta radiobiolohii [Probl Radiac Med Radiobiol] 2013 (18), pp. 356-65. |
| نوع المنشور: | Journal Article |
| اللغة: | English; Ukrainian |
| بيانات الدورية: | Publisher: Naukovyĭ t︠s︡entr radiat︠s︡iĭnoï medyt︠s︡yny AMN Ukraïny Country of Publication: Ukraine NLM ID: 101560511 Publication Model: Print Cited Medium: Print ISSN: 2304-8336 (Print) Linking ISSN: 23048336 NLM ISO Abbreviation: Probl Radiac Med Radiobiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kyïv : Naukovyĭ t︠s︡entr radiat︠s︡iĭnoï medyt︠s︡yny AMN Ukraïny |
| مواضيع طبية MeSH: | Hematopoiesis*/drug effects , Hematopoiesis*/radiation effects, Ethanolamines/*adverse effects , Gamma Rays/*adverse effects , Radiation Injuries, Experimental/*blood , Radiation-Protective Agents/*adverse effects , Stearic Acids/*adverse effects, Animals ; Blood Cell Count ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Drug Administration Schedule ; Ethanolamines/administration & dosage ; Ethanolamines/therapeutic use ; Male ; Radiation Dosage ; Radiation Injuries, Experimental/prevention & control ; Radiation-Protective Agents/administration & dosage ; Radiation-Protective Agents/therapeutic use ; Rats ; Stearic Acids/administration & dosage ; Stearic Acids/therapeutic use ; Whole-Body Irradiation |
| مستخلص: | Unlabelled: The study objective was to explore the peculiarities of peripheral blood values in rats under the combined influence of 10.0 mg/kg N-stearoylethanolamine (NSE) and 6.0 Gy dose of ionizing radiation to identify the radiomodifying properties of the drug. Methods: hematological, statistical. Results: it was found that NSE injection to irradiated rats leads to exacerbation of hematopoietic system disorders indicating to radiosensitizing effect of the substance. Conclusions: The radiosensitizing effect of the drug was established according to qualitative and quantitative abnormalities in peripheral blood values of the rats. Effect of the NSE drug on the rate of recovery processes (i.e. retardation) in the peripheral blood of rats after irradiation was established under these experimental conditions. (Rodionova N. K., Atamanjuk N. P., Derevjanko L. P., Talko V. V., Janina A. M., Shelkovskyj M. V., Kosjakova G. V., Meged O. F., Gula N. M., Chumak A. A., 2013.) |
| فهرسة مساهمة: | Keywords: N-stearoyilethanolamine; hematological parameters; ionizing radiation; peripheral blood Local Abstract: [Publisher, Ukrainian] Meta doslidzhennja – vyvchyty osoblyvosti zmin gematologichnyh pokaznykiv peryferychnoi' krovi shhuriv v umovah kombinovanogo vplyvu N-ctearoi'letanolaminu (NSE) (10,0 mg/kg) ta ionizujuchogo vyprominennja (6,0 Gr) dlja vyjavlennja radiomodyfikujuchyh vlastyvostej preparata. Metody: gematologichni, statystychni. Rezul'taty. Za danyh umov eksperymentu vvedennja NSE oprominenym shhuram pryzvodylo do zbil'shennja oznak urazhennja krovotvornoi' systemy, shho svidchyt' pro jogo radiosensybilizujuchu diju. Vysnovky. V umovah kombinovanogo vplyvu NSE ta odnorazovogo oprominennja na osnovi jakisnyh ta kil'kisnyh zmin gematologichnyh pokaznykiv peryferychnoi' krovi shhuriv vstanovlena radiosensybilizujucha dija preparatu. Za danyh umov eksperymentu vstanovlenyj vplyv preparatu NSE na shvydkist' vidnovnyh procesiv (spovil'nennja) u peryferychnij krovi shhuriv pislja oprominennja. |
| المشرفين على المادة: | 0 (Ethanolamines) 0 (N-stearoylethanolamine) 0 (Radiation-Protective Agents) 0 (Stearic Acids) |
| تواريخ الأحداث: | Date Created: 20140906 Date Completed: 20150205 Latest Revision: 20140906 |
| رمز التحديث: | 20231215 |
| PMID: | 25191741 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2304-8336 |
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