دورية أكاديمية
أعرض في EDS

Alzheimer's disease and HLA-A2: linking neurodegenerative to immune processes through an in silico approach.

التفاصيل البيبلوغرافية
العنوان: Alzheimer's disease and HLA-A2: linking neurodegenerative to immune processes through an in silico approach.
المؤلفون: Cifuentes RA; Area of Basic Sciences, Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia., Murillo-Rojas J; Area of Basic Sciences, Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia.
المصدر: BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 791238. Date of Electronic Publication: 2014 Aug 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Co.
مواضيع طبية MeSH: Computer Simulation*, Alzheimer Disease/*immunology , HLA-A2 Antigen/*immunology , Nerve Degeneration/*immunology, Alzheimer Disease/complications ; Alzheimer Disease/genetics ; Gene Regulatory Networks ; HLA-A2 Antigen/genetics ; Humans ; Nerve Degeneration/complications ; Nerve Degeneration/pathology ; Odds Ratio
مستخلص: There is a controversial relationship between HLA-A2 and Alzheimer's disease (AD). It has been suggested a modifier effect on the risk that depends on genetic loadings. Thus, the aims of this study were to evaluate this relationship and to reveal genes associated with both concepts the HLA-A gene and AD. Consequently, we did first a classical systematic review and a meta-analysis of case-control studies. Next, by means of an in silico approach, we used experimental knowledge of protein-protein interactions to evaluate the top ranked genes shared by both concepts, previously found through text mining. The meta-analysis did not show a significant pooled OR (1.11, 95% CI: 0.98 to 1.24 in Caucasians), in spite of the fact that four of the included studies had a significant OR > 1 and none of them a significant OR < 1. In contrast, the in silico approach retrieved nonrandomly shared genes by both concepts (P = 0.02), which additionally encode truly interacting proteins. The network of proteins encoded by APP, ICAM-1, ITGB2, ITGAL, SELP, SELL, IL2, IL1B, CD4, and CD8A linked immune to neurodegenerative processes and highlighted the potential roles in AD pathogenesis of endothelial regulation, infectious diseases, specific antigen presentation, and HLA-A2 in maintaining synapses.
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المشرفين على المادة: 0 (HLA-A2 Antigen)
تواريخ الأحداث: Date Created: 20140909 Date Completed: 20150629 Latest Revision: 20220409
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4150521
DOI: 10.1155/2014/791238
PMID: 25197660
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6141
DOI:10.1155/2014/791238