دورية أكاديمية
أعرض في EDS

Evaluation of the extent of pulmonary cysts and their association with functional variables and serum markers in lymphangioleiomyomatosis (LAM).

التفاصيل البيبلوغرافية
العنوان: Evaluation of the extent of pulmonary cysts and their association with functional variables and serum markers in lymphangioleiomyomatosis (LAM).
المؤلفون: Baldi BG; Pulmonary Division, Heart Institute (InCor), University of Sao Paulo Medical School, Dr. Enéas de Carvalho Aguiar Avenue, 44, Fifth floor, São Paulo, 05403-900, Brazil, bruno.guedes2@terra.com.br., Araujo MS, Freitas CS, da Silva Teles GB, Kairalla RA, Dias OM, Pereira DA, Pimenta SP, Carvalho CR
المصدر: Lung [Lung] 2014 Dec; Vol. 192 (6), pp. 967-74. Date of Electronic Publication: 2014 Sep 09.
نوع المنشور: Comparative Study; Evaluation Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: United States NLM ID: 7701875 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1750 (Electronic) Linking ISSN: 03412040 NLM ISO Abbreviation: Lung Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer Verlag
Original Publication: Heidelberg, Springer International.
مواضيع طبية MeSH: Cysts/*diagnostic imaging , Lung Neoplasms/*diagnostic imaging , Lymphangioleiomyomatosis/*diagnostic imaging, Adult ; Biomarkers/analysis ; Cross-Sectional Studies ; Cysts/blood ; Cysts/epidemiology ; Disease Progression ; Exercise Test/methods ; Female ; Follow-Up Studies ; Humans ; Lung Diseases/blood ; Lung Diseases/diagnostic imaging ; Lung Diseases/epidemiology ; Lung Neoplasms/blood ; Lung Neoplasms/epidemiology ; Lymphangioleiomyomatosis/blood ; Lymphangioleiomyomatosis/epidemiology ; Matrix Metalloproteinase 2/blood ; Matrix Metalloproteinase 9/blood ; Middle Aged ; Respiratory Function Tests ; Risk Assessment ; Severity of Illness Index ; Tomography, X-Ray Computed/methods ; Vascular Endothelial Growth Factor A/blood
مستخلص: Purpose: Although computed tomography (CT) has been used previously to assess disease severity in lymphangioleiomyomatosis (LAM), the associations between the extent of pulmonary cysts on CT and six-minute walk test (6MWT), matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF-D) are not well established. We performed a cross-sectional study to quantify the extent of pulmonary cysts in CT and to establish their correlations with pulmonary function tests (PFTs), 6MWT results, including a composite index (desaturation-distance ratio, DDR), and levels of VEGF-D and MMPs in LAM.
Methods: Twenty-three LAM patients underwent CT scanning to automatically quantify the extent of pulmonary cysts and performed PFTs and 6MWT. Serum levels of MMP-2, MMP-9, and VEGF-D were also measured.
Results: The severity of pulmonary cystic involvement was mild (the extent of cysts was 6.8 %) and correlated best with FEV1/FVC (r = -0.84), residual volume (r = 0.66), DLCO (r = -0.82), the DDR index (r = 0.77), and desaturation during the 6MWT (r = -0.81). There was a weak correlation with VEGF-D (r = 0.45), but no association was found with MMP-2 and MMP-9.
Conclusions: The severity of pulmonary cystic involvement was mild in this sample of LAM patients and correlated best with airway obstruction, air trapping, reduced DLCO, the DDR index, and desaturation during the 6MWT. Serum VEGF-D cannot be completely defined as a valuable marker of disease severity and there may be a mechanism independent of MMPs to explain the formation of pulmonary cysts.
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المشرفين على المادة: 0 (Biomarkers)
0 (Vascular Endothelial Growth Factor A)
EC 3.4.24.24 (Matrix Metalloproteinase 2)
EC 3.4.24.35 (Matrix Metalloproteinase 9)
تواريخ الأحداث: Date Created: 20140910 Date Completed: 20150717 Latest Revision: 20211021
رمز التحديث: 20240628
DOI: 10.1007/s00408-014-9641-2
PMID: 25201087
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1750
DOI:10.1007/s00408-014-9641-2