دورية أكاديمية
أعرض في EDS

An ankyrin repeat domain of AKR2 drives chloroplast targeting through coincident binding of two chloroplast lipids.

التفاصيل البيبلوغرافية
العنوان: An ankyrin repeat domain of AKR2 drives chloroplast targeting through coincident binding of two chloroplast lipids.
المؤلفون: Kim DH; Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea., Park MJ; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, Korea., Gwon GH; Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea., Silkov A; Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 11032, USA., Xu ZY; Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea., Yang EC; Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, Korea., Song S; Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA., Song K; Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea., Kim Y; Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea., Yoon HS; Department of Biological Sciences, Sungkyunkwan University, Suwon 440-746, Korea., Honig B; Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY 11032, USA., Cho W; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, Korea; Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA. Electronic address: wcho@uic.edu., Cho Y; Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea. Electronic address: yunje@postech.ac.kr., Hwang I; Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790-784, Korea; Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, Korea. Electronic address: ihhwang@postech.ac.kr.
المصدر: Developmental cell [Dev Cell] 2014 Sep 08; Vol. 30 (5), pp. 598-609.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print Cited Medium: Internet ISSN: 1878-1551 (Electronic) Linking ISSN: 15345807 NLM ISO Abbreviation: Dev Cell Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, Mass. : Cell Press, c2001-
مواضيع طبية MeSH: Ankyrin Repeat*, Arabidopsis/*metabolism , Arabidopsis Proteins/*chemistry , Chloroplasts/*metabolism , Lipids/*chemistry , Molecular Chaperones/*chemistry, Amino Acid Sequence ; Arabidopsis Proteins/metabolism ; Arabidopsis Proteins/physiology ; Binding Sites ; Cyanobacteria/metabolism ; Cytosol/metabolism ; Galactolipids/chemistry ; Models, Molecular ; Molecular Chaperones/physiology ; Molecular Sequence Data ; Phosphatidylglycerols/chemistry ; Protein Binding ; Protein Structure, Tertiary ; Sequence Homology, Amino Acid ; Symbiosis
مستخلص: In organellogenesis of the chloroplast from endosymbiotic cyanobacteria, the establishment of protein-targeting mechanisms to the chloroplast should have been pivotal. However, it is still mysterious how these mechanisms were established and how they work in plant cells. Here we show that AKR2A, the cytosolic targeting factor for chloroplast outer membrane (COM) proteins, evolved from the ankyrin repeat domain (ARD) of the host cell by stepwise extensions of its N-terminal domain and that two lipids, monogalactosyldiacylglycerol (MGDG) and phosphatidylglycerol (PG), of the endosymbiont were selected to function as the AKR2A receptor. Structural analysis, molecular modeling, and mutational analysis of the ARD identified two adjacent sites for coincidental and synergistic binding of MGDG and PG. Based on these findings, we propose that the targeting mechanism of COM proteins was established using components from both the endosymbiont and host cell through a modification of the protein-protein-interacting ARD into a lipid binding domain.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Dev Cell. 2014 Sep 8;30(5):493-5. (PMID: 25203205)
References: Mol Cell. 2012 Apr 27;46(2):226-37. (PMID: 22445486)
Biochim Biophys Acta. 2013 Feb;1833(2):332-40. (PMID: 22521451)
Methods Enzymol. 1997;276:307-26. (PMID: 27754618)
Nat Rev Genet. 2004 Feb;5(2):123-35. (PMID: 14735123)
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17216-21. (PMID: 17940034)
J Biol Chem. 2008 Mar 7;283(10):6126-35. (PMID: 18174168)
Plant Cell. 2001 Jul;13(7):1511-26. (PMID: 11449048)
Biochim Biophys Acta. 2012 Mar;1818(3):673-8. (PMID: 22079564)
J Cell Biol. 1985 May;100(5):1690-7. (PMID: 3988805)
Curr Opin Struct Biol. 2008 Feb;18(1):27-34. (PMID: 18243686)
Antimicrob Agents Chemother. 2009 Apr;53(4):1598-609. (PMID: 19164152)
Biochemistry. 1985 Aug 13;24(17):4645-50. (PMID: 2933071)
Nat Chem. 2011 Oct 09;3(11):868-74. (PMID: 22024883)
Curr Biol. 2010 Dec 21;20(24):2217-22. (PMID: 21145743)
Plant J. 2003 Mar;33(5):899-909. (PMID: 12609031)
Traffic. 2013 Jun;14(6):613-21. (PMID: 23331847)
J Biol Chem. 2003 Nov 21;278(47):46886-94. (PMID: 12954613)
Mol Biol Cell. 2001 Dec;12(12):4090-102. (PMID: 11739803)
J Cell Sci. 2003 Mar 1;116(Pt 5):837-46. (PMID: 12571281)
Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8175-9. (PMID: 10869420)
J Comput Chem. 2004 Oct;25(13):1605-12. (PMID: 15264254)
Biochim Biophys Acta. 2011 Apr;1808(4):1154-60. (PMID: 21223947)
Science. 2004 Apr 9;304(5668):253-7. (PMID: 15073369)
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12246-51. (PMID: 12218172)
Annu Rev Biochem. 2001;70:755-75. (PMID: 11395422)
PLoS One. 2010 Apr 14;5(4):e10098. (PMID: 20418952)
Antimicrob Agents Chemother. 2011 Sep;55(9):4326-37. (PMID: 21709092)
Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):333-7. (PMID: 8990209)
Mol Cells. 2004 Apr 30;17(2):281-91. (PMID: 15179043)
Nat Commun. 2012;3:1249. (PMID: 23212378)
Plant Physiol. 2011 Sep;157(1):132-46. (PMID: 21730198)
Annu Rev Genet. 2007;41:147-68. (PMID: 17600460)
J Biol Chem. 1998 Jun 26;273(26):16583-8. (PMID: 9632730)
Trends Biochem Sci. 1996 Jul;21(7):267-71. (PMID: 8755249)
Biochim Biophys Acta. 2010 Jun;1803(6):724-31. (PMID: 20079383)
J Biol Chem. 1983 Nov 10;258(21):13281-6. (PMID: 6630230)
Plant Cell. 2001 Oct;13(10):2175-90. (PMID: 11595795)
Anal Biochem. 2001 Sep 15;296(2):153-61. (PMID: 11554709)
Cell. 1996 Feb 9;84(3):395-400. (PMID: 8608593)
Trends Cell Biol. 1999 Jun;9(6):222-7. (PMID: 10354568)
J Biol Chem. 2008 Jun 20;283(25):17107-15. (PMID: 18434318)
Annu Rev Biophys Biomol Struct. 2005;34:119-51. (PMID: 15869386)
Plant Cell. 1999 Apr;11(4):557-70. (PMID: 10213778)
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32. (PMID: 15572765)
Front Plant Sci. 2014 Apr 29;5:173. (PMID: 24808904)
Trends Plant Sci. 2005 Sep;10(9):450-7. (PMID: 16085449)
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21. (PMID: 20124702)
Nature. 2006 Oct 12;443(7112):651-7. (PMID: 17035995)
Nat Cell Biol. 2008 Feb;10(2):220-7. (PMID: 18193034)
Plant Cell. 2001 Feb;13(2):287-301. (PMID: 11226186)
Plant Cell. 2004 Aug;16(8):2078-88. (PMID: 15258267)
Protein Sci. 2004 Jun;13(6):1435-48. (PMID: 15152081)
Biochemistry. 2006 Dec 26;45(51):15168-78. (PMID: 17176038)
Plant Physiol. 2002 Jun;129(2):594-604. (PMID: 12068104)
Annu Rev Biophys Biomol Struct. 2002;31:151-75. (PMID: 11988466)
Biochemistry. 1999 Dec 7;38(49):16290-7. (PMID: 10587453)
معلومات مُعتمدة: R01 GM068849 United States GM NIGMS NIH HHS; R01 GM030518 United States GM NIGMS NIH HHS; R01 GM110128 United States GM NIGMS NIH HHS; GM68849 United States GM NIGMS NIH HHS; U54 GM094597 United States GM NIGMS NIH HHS; R37 GM030518 United States GM NIGMS NIH HHS; GM30518 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (AKR2 protein, Arabidopsis)
0 (Arabidopsis Proteins)
0 (Galactolipids)
0 (Lipids)
0 (Molecular Chaperones)
0 (Phosphatidylglycerols)
0 (monogalactosyldiacylglycerol)
تواريخ الأحداث: Date Created: 20140910 Date Completed: 20141110 Latest Revision: 20211021
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4170656
DOI: 10.1016/j.devcel.2014.07.026
PMID: 25203210
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-1551
DOI:10.1016/j.devcel.2014.07.026