دورية أكاديمية
Hemi-Descemet membrane endothelial keratoplasty transplantation: a potential method for increasing the pool of endothelial graft tissue.
| العنوان: | Hemi-Descemet membrane endothelial keratoplasty transplantation: a potential method for increasing the pool of endothelial graft tissue. |
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| المؤلفون: | Lam FC; Netherlands Institute for Innovative Ocular Surgery, Rotterdam, the Netherlands2Melles Cornea Clinic Rotterdam, Rotterdam, the Netherlands., Baydoun L; Netherlands Institute for Innovative Ocular Surgery, Rotterdam, the Netherlands2Melles Cornea Clinic Rotterdam, Rotterdam, the Netherlands., Dirisamer M; Netherlands Institute for Innovative Ocular Surgery, Rotterdam, the Netherlands2Melles Cornea Clinic Rotterdam, Rotterdam, the Netherlands3Allgemeines Krankenhaus Linz, Linz, Austria., Lie J; Netherlands Institute for Innovative Ocular Surgery, Rotterdam, the Netherlands4Amnitrans EyeBank Rotterdam, Rotterdam, the Netherlands., Dapena I; Netherlands Institute for Innovative Ocular Surgery, Rotterdam, the Netherlands2Melles Cornea Clinic Rotterdam, Rotterdam, the Netherlands., Melles GR; Netherlands Institute for Innovative Ocular Surgery, Rotterdam, the Netherlands2Melles Cornea Clinic Rotterdam, Rotterdam, the Netherlands4Amnitrans EyeBank Rotterdam, Rotterdam, the Netherlands. |
| المصدر: | JAMA ophthalmology [JAMA Ophthalmol] 2014 Dec; Vol. 132 (12), pp. 1469-73. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101589539 Publication Model: Print Cited Medium: Internet ISSN: 2168-6173 (Electronic) Linking ISSN: 21686165 NLM ISO Abbreviation: JAMA Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago, IL : American Medical Association, [2013]- |
| مواضيع طبية MeSH: | Tissue Donors* , Tissue and Organ Procurement*, Descemet Stripping Endothelial Keratoplasty/*methods , Fuchs' Endothelial Dystrophy/*surgery, Aged ; Cell Count ; Corneal Pachymetry ; Endothelium, Corneal/pathology ; Female ; Fuchs' Endothelial Dystrophy/physiopathology ; Humans ; Intraoperative Complications ; Postoperative Complications ; Prospective Studies ; Visual Acuity/physiology |
| مستخلص: | Importance: This study evaluates the technical feasibility and clinical outcomes of a Descemet membrane endothelial keratoplasty (DMEK) technique that could increase the availability of donor tissue for DMEK. Objective: To evaluate the clinical outcome of using a semicircular, large-diameter Descemet membrane graft in DMEK (hemi-DMEK), potentially allowing the use of a single donor cornea for 2 DMEK procedures. Design, Setting, and Participants: A prospective, interventional case series was conducted at a tertiary referral center. Three eyes of 3 patients with Fuchs endothelial dystrophy received a hemi-DMEK. Intervention: Transplantation of a semicircular, large-diameter hemi-DMEK graft. Main Outcomes and Measures: Best-corrected visual acuity, endothelial cell density, pachymetry, and intraoperative and postoperative complications. Results: The patients' best-corrected visual acuity at 6 months was 0.70 (Snellen equivalent, 20/29), 0.50 (20/40 [amblyopic eye]), and 1.20 (20/17). At 1 month, endothelial cell density decreased by 49%, 31%, and 39%, respectively, and endothelial cell migration appeared to continue for up to 6 months. Central corneal thicknesses decreased from 682, 707, and 681 μm before surgery to 523, 534, and 489 μm, respectively, at 6 months. No intraoperative or postoperative complications were seen. Conclusions and Relevance: Hemi-DMEK (using half-moon-shaped grafts) is technically feasible and may provide visual outcomes similar to those obtained with routine DMEK (full-moon-shaped graft). If so, this technique may have the potential to double the availability of donor endothelial tissue for DMEK surgery. |
| تواريخ الأحداث: | Date Created: 20140912 Date Completed: 20150304 Latest Revision: 20151119 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1001/jamaophthalmol.2014.3328 |
| PMID: | 25211529 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2168-6173 |
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| DOI: | 10.1001/jamaophthalmol.2014.3328 |