دورية أكاديمية
Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells.
| العنوان: | Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells. |
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| المؤلفون: | De Aquino Xavier FC, Prates AA, Gurgel CA, De Souza TG, Andrade RG, Goncalves Ramos EA, Pedreira Ramalho LM, Dos Santos JN; Federal University of Bahia, Brazil. |
| المصدر: | Dermatology online journal [Dermatol Online J] 2014 Sep 16; Vol. 20 (9). Date of Electronic Publication: 2014 Sep 16. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: University of California, Davis Country of Publication: United States NLM ID: 9610776 Publication Model: Electronic Cited Medium: Internet ISSN: 1087-2108 (Electronic) Linking ISSN: 10872108 NLM ISO Abbreviation: Dermatol Online J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Davis, Calif.] : University of California, Davis, c1995- |
| مواضيع طبية MeSH: | Extracellular Matrix Proteins/*metabolism , Immunoglobulin G/*metabolism , Lichen Sclerosus et Atrophicus/*metabolism , Mouth Diseases/*metabolism , Plasma Cells/*metabolism, Collagen Type IV/metabolism ; Fibronectins/metabolism ; Humans ; Immunoenzyme Techniques ; Lichen Sclerosus et Atrophicus/pathology ; Male ; Matrix Metalloproteinase 9/metabolism ; Middle Aged ; Mouth Mucosa/metabolism ; Tenascin/metabolism |
| مستخلص: | Lichen sclerosus (LS) is a mucocutaneous disease with uncommon oral involvement. The etiology is not yet well understood, but LS has been associated with autoimmune, genetic, and immunological factors. We report a 47-year-old man with LS that exhibited an asymptomatic white plaque with red patches on the maxillary alveolar mucosa extending to the labial mucosa. He had no other skin disease. Positive immunostaining for tenascin and scarcity of fibronectin suggested extracellular matrix reorganization. Elastin immunostaining indicated a reduction of elastic fibers. Immunoexpression of collagen IV in blood vessels and its absence in the epithelial basement membrane, together with diffuse MMP-9 immunoexpression, suggested altered proteolytic activity. Mast cell staining bordering areas of sclerosis indicated a possible role in the synthesis of collagen. IgG4 positivity in plasma cells suggested a role in the fibrogenesis. This is an unusual presentation of oral LS and we discuss immunohistochemical findings regarding cellular and extracellular matrix components. |
| المشرفين على المادة: | 0 (Collagen Type IV) 0 (Extracellular Matrix Proteins) 0 (Fibronectins) 0 (Immunoglobulin G) 0 (Tenascin) EC 3.4.24.35 (Matrix Metalloproteinase 9) |
| تواريخ الأحداث: | Date Created: 20140923 Date Completed: 20150521 Latest Revision: 20220331 |
| رمز التحديث: | 20240628 |
| PMID: | 25244166 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1087-2108 |
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