دورية أكاديمية
The protective role of bee honey against the toxic effect of melamine in the male rat kidney.
| العنوان: | The protective role of bee honey against the toxic effect of melamine in the male rat kidney. |
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| المؤلفون: | Al-Seeni MN; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia., El Rabey HA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia Genetic Engineering and Biotechnology Institute, Sadat City University, Sadat, Minufiya, Egypt elrabey@hotmail.com., Al-Solamy SM; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. |
| المصدر: | Toxicology and industrial health [Toxicol Ind Health] 2015 Jun; Vol. 31 (6), pp. 485-93. Date of Electronic Publication: 2014 Sep 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: England NLM ID: 8602702 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0393 (Electronic) Linking ISSN: 07482337 NLM ISO Abbreviation: Toxicol Ind Health Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : SAGE Publications Original Publication: Princeton, N.J. : Princeton Scientific Pub. Co. |
| مواضيع طبية MeSH: | Honey*, Kidney/*drug effects , Protective Agents/*pharmacology , Renal Insufficiency/*chemically induced , Triazines/*toxicity, Animals ; Antioxidants/metabolism ; Catalase/biosynthesis ; Glutathione Transferase/biosynthesis ; Kidney Function Tests ; Lipid Peroxidation/drug effects ; Male ; Potassium/blood ; Rats |
| مستخلص: | This study aimed to test the protective role of natural bee honey against melamine toxicity in the kidney of male albino rats. The dietary supplementation of melamine at a dose of 20,000 ppm for 28 days induced renal dysfunction, as reflected by a significant increase in kidney function parameters (urea, creatinine, and uric acid) and an increase in potassium levels. In addition, a decrease in catalase and glutathione-S-transferase and an increase in lipid peroxide in the kidney tissue homogenate were also observed. Histological changes in the melamine-treated group revealed hyperplasia and damage in kidney cells and the accumulation of melamine crystals in kidney tissues. Honey treatment for 28 days in rats concurrently administered melamine at a dose of 2.5 g/kg body weight for 28 days improved the kidney function, increased antioxidant enzymes, and decreased lipid peroxide levels. The morphology of the kidney cells of the melamine-fed rats was also improved as a result of honey treatment. In conclusion, this study revealed that natural bee honey protects the kidney against the adverse effects induced by melamine toxicity in male albino rats. (© The Author(s) 2014.) |
| فهرسة مساهمة: | Keywords: Melamine; catalase; creatinine; honey; kidney |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Protective Agents) 0 (Triazines) EC 1.11.1.6 (Catalase) EC 2.5.1.18 (Glutathione Transferase) N3GP2YSD88 (melamine) RWP5GA015D (Potassium) |
| تواريخ الأحداث: | Date Created: 20140927 Date Completed: 20160218 Latest Revision: 20220330 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1177/0748233714551765 |
| PMID: | 25258397 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1477-0393 |
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| DOI: | 10.1177/0748233714551765 |