دورية أكاديمية
أعرض في EDS

A comparison of virulence patterns and in vivo fitness between hospital- and community-acquired methicillin-resistant Staphylococcus aureus related to the USA400 clone.

التفاصيل البيبلوغرافية
العنوان: A comparison of virulence patterns and in vivo fitness between hospital- and community-acquired methicillin-resistant Staphylococcus aureus related to the USA400 clone.
المؤلفون: Guimarães MA; Departamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Ramundo MS, Américo MA, de Mattos MC, Souza RR, Ramos-Júnior ES, Coelho LR, Morrot A, Melo PA, Fracalanzza SE, Ferreira FA, Figueiredo AM
المصدر: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2015 Mar; Vol. 34 (3), pp. 497-509. Date of Electronic Publication: 2014 Oct 14.
نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Berlin : Springer
Original Publication: [Wiesbaden, Federal Republic of Germany] : Vieweg, [c1988-
مواضيع طبية MeSH: Community-Acquired Infections/*microbiology , Cross Infection/*microbiology , Methicillin-Resistant Staphylococcus aureus/*genetics , Methicillin-Resistant Staphylococcus aureus/*physiology , Staphylococcal Infections/*microbiology , Virulence Factors/*genetics, Animals ; Biological Evolution ; Brazil ; Disease Models, Animal ; Female ; Gene Expression Profiling ; Genes, Bacterial ; Genotype ; Humans ; Methicillin-Resistant Staphylococcus aureus/growth & development ; Methicillin-Resistant Staphylococcus aureus/isolation & purification ; Mice ; United States ; Virulence
مستخلص: Methicillin-resistant Staphylococcus aureus (MRSA) isolates genetically related to the CA-MRSA clone MW2/USA400 (ST1-SCCmecIV lineage) from the United States have emerged in hospitals in Rio de Janeiro and are associated with nosocomial bloodstream infections. To understand the virulence mechanisms involved in the adaptability of ST1 isolates as a hospital pathogen in Rio de Janeiro, we compared the virulence traits and fitness properties of the Brazilian isolates with those displayed by the CA-MRSA isolates from the United States. Similar to the USA400 from the United States, all the Brazilian isolates tested carried the genes encoding SEH and LukDE. In contrast, none of the Brazilian isolates carried the lukSF PVL, sea, sec, and sek genes. Competition experiments in mice demonstrated a significant increase in the fitness for the CA-MRSA isolates MW2 and USA400-0051 from the United States compared to other isolates. In the foreign body animal model, 83 % more North-American bacterial cells were recovered compared to the Brazilian ST1 isolates. Differences in gene expression of important virulence factors were detected. Transcription of rnaIII and psmα3 was increased about two-fold in the isolates from the United States, and sasG about two-fold in the Brazilian isolates. Thus, it is possible that the virulence attenuation observed among the Brazilian hospital isolates, associated with the acquisition of multiple resistant determinants, are consequences of microevolutionary events that contributed to the necessary fitness adjustment of this lineage, allowing a typically community-acquired MRSA (MW2/USA400) to emerge as a successful hospital pathogen (Brazilian ST1-SCCmecIV).
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المشرفين على المادة: 0 (Virulence Factors)
تواريخ الأحداث: Date Created: 20141015 Date Completed: 20151109 Latest Revision: 20211021
رمز التحديث: 20221213
DOI: 10.1007/s10096-014-2253-1
PMID: 25311987
قاعدة البيانات: MEDLINE
الوصف
تدمد:1435-4373
DOI:10.1007/s10096-014-2253-1