دورية أكاديمية
Bioassay of teicoplanin in serum containing rifampin or a beta-lactam antibiotic.
| العنوان: | Bioassay of teicoplanin in serum containing rifampin or a beta-lactam antibiotic. |
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| المؤلفون: | Kenny MT; Merrell Dow Research Institute, Indianapolis, IN 46268., Dulworth JK, Brackman MA, Torney HL, Gibson CB, Hildebrand AR, Weckbach LS, Staneck JL |
| المصدر: | Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 1989 Sep-Oct; Vol. 12 (5), pp. 449-54. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8305899 Publication Model: Print Cited Medium: Print ISSN: 0732-8893 (Print) Linking ISSN: 07328893 NLM ISO Abbreviation: Diagn Microbiol Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [New York, NY] : Elsevier Biomedical, [c1983- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*blood , Rifampin/*blood, Analysis of Variance ; Biological Assay ; Glycopeptides/blood ; Humans ; Regression Analysis ; Teicoplanin ; beta-Lactams |
| مستخلص: | The purpose of this study was to develop bioassays for the measurement of teicoplanin in serum containing rifampin or a beta-lactam antibiotic. Use of rifampin-resistant Bacillus subtilis as indicator organism or pretreatment of the serum sample with Bacillus cereus penicillinase Type I (nafcillin, ticarcillin, mezlocillin) or Type II (cefazolin, cefuroxime, ceftazidime, ceftriaxone) effectively eliminated assay interference. Validation bioassays performed on two separate days utilizing triplicate coded serum samples containing 0 to 200 micrograms teicoplanin in combination with 40 micrograms/ml rifampin or 200 to 500 micrograms/ml beta-lactam showed no significant differences (p greater than 0.05, two-way analysis of variance) in analyte recovery between assay days. Regression analysis of each teicoplanin/rifampin or teicoplanin/beta-lactam data set yielded slope values of 0.92 to 1.01, intercept values of -0.45 to 0.84 and correlation coefficients of 0.9925 to 0.9990. Thus, serum teicoplanin can be quantitated accurately, precisely, and reproducibly in patients receiving concomitant rifampin or beta-lactam chemotherapy. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Glycopeptides) 0 (beta-Lactams) 61036-62-2 (Teicoplanin) VJT6J7R4TR (Rifampin) |
| تواريخ الأحداث: | Date Created: 19890901 Date Completed: 19900307 Latest Revision: 20190903 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0732-8893(89)90119-3 |
| PMID: | 2533051 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0732-8893 |
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| DOI: | 10.1016/0732-8893(89)90119-3 |