دورية أكاديمية
Cytotoxic vobasine, tacaman, and corynanthe-tryptamine bisindole alkaloids from Tabernaemontana and structure revision of tronoharine.
| العنوان: | Cytotoxic vobasine, tacaman, and corynanthe-tryptamine bisindole alkaloids from Tabernaemontana and structure revision of tronoharine. |
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| المؤلفون: | Sim DS; Department of Chemistry and ‡Institute of Biological Sciences, University of Malaya , 50603 Kuala Lumpur, Malaysia., Chong KW, Nge CE, Low YY, Sim KS, Kam TS |
| المصدر: | Journal of natural products [J Nat Prod] 2014 Nov 26; Vol. 77 (11), pp. 2504-12. Date of Electronic Publication: 2014 Oct 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | Antineoplastic Agents, Phytogenic/*isolation & purification , Antineoplastic Agents, Phytogenic/*pharmacology , Indole Alkaloids/*isolation & purification , Indole Alkaloids/*pharmacology , Plants, Medicinal/*chemistry , Tabernaemontana/*chemistry, Antineoplastic Agents, Phytogenic/chemistry ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; Humans ; Indole Alkaloids/chemistry ; Indoles/chemistry ; Indoles/isolation & purification ; Indoles/pharmacology ; Malaysia ; Molecular Conformation ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Pausinystalia ; Tryptamines/chemistry ; Tryptamines/isolation & purification ; Tryptamines/pharmacology |
| مستخلص: | Seven new indole alkaloids (1-7) comprising four vobasine, two tacaman, and one corynanthe-tryptamine bisindole alkaloid were isolated from the stem-bark extract of a Malayan Tabernaemontana. Two of the new vobasine alkaloids (1, 3), as well as 16-epivobasine (15) and 16-epivobasenal (17), showed appreciable cytotoxicity toward KB cells (IC50 ca. 5 μg/mL). The structure of the known Tabernaemontana alkaloid tronoharine (8) was revised based on newly acquired NMR data, as well as X-ray diffraction analysis. |
| المشرفين على المادة: | 0 (Antineoplastic Agents, Phytogenic) 0 (Indole Alkaloids) 0 (Indoles) 0 (Tryptamines) 0 (tacaman) 2134-83-0 (vobasine) 422ZU9N5TV (tryptamine) |
| تواريخ الأحداث: | Date Created: 20141022 Date Completed: 20150708 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1021/np500589u |
| PMID: | 25333996 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6025 |
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| DOI: | 10.1021/np500589u |