دورية أكاديمية
أعرض في EDS

A new combination therapy in severe acute pancreatitis--hyperbaric oxygen plus 3-aminobenzamide: an experimental study.

التفاصيل البيبلوغرافية
العنوان: A new combination therapy in severe acute pancreatitis--hyperbaric oxygen plus 3-aminobenzamide: an experimental study.
المؤلفون: Inal V; From the *Department of Intensive Care, Internal Medicine, Trakya University Faculty of Medicine, Edirne; Departments of †Geriatrics, and ‡Intensive Care, Internal Medicine, Dokuz Eylul University Faculty of Medicine, Izmir; §Department of Surgery, Guven Hospital, Ankara; ∥Department of Anatomy, Dokuz Eylul University Faculty of Medicine, Izmir; and Departments of ¶Pathology, #Internal Medicine, **Intensive Care, Internal Medicine, and ††Infection Disease, Gulhane School of Medicine, Ankara, Turkey., Mas MR, Isik AT, Comert B, Aydn S, Mas N, Deveci MS, Tasci I, Yamanel L, Cinar E, Unal MT
المصدر: Pancreas [Pancreas] 2015 Mar; Vol. 44 (2), pp. 326-30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8608542 Publication Model: Print Cited Medium: Internet ISSN: 1536-4828 (Electronic) Linking ISSN: 08853177 NLM ISO Abbreviation: Pancreas Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: [New York, N.Y.] : Raven Press, [c1986-
مواضيع طبية MeSH: Hyperbaric Oxygenation*, Benzamides/*pharmacology , Enzyme Inhibitors/*pharmacology , Pancreas/*drug effects , Pancreatitis/*therapy, Acute Disease ; Animals ; Bacterial Translocation/drug effects ; Combined Modality Therapy ; Disease Models, Animal ; Male ; Oxidative Stress/drug effects ; Pancreas/metabolism ; Pancreas/microbiology ; Pancreas/pathology ; Pancreatitis/chemically induced ; Pancreatitis/metabolism ; Pancreatitis/microbiology ; Pancreatitis/pathology ; Poly(ADP-ribose) Polymerase Inhibitors ; Poly(ADP-ribose) Polymerases/metabolism ; Severity of Illness Index ; Taurocholic Acid ; Time Factors
مستخلص: Objectives: This study was designed to evaluate effects of hyperbaric oxygen (HBO) plus 3-aminobenzamide (3-AB) cotreatment on tissue oxidative stress parameters (TOSp), tissue histopathology scores (THSc), and bacterial translocations (Bact-Trans) in an experimental model of severe acute pancreatitis (AP).
Methods: Seventy-five Sprague-Dawley rats were randomized into 5 groups. Group 1 received sham. Severe AP was induced by intraductal taurocholate infusion and then group 2 received saline, group 3 received 3-AB, group 4 received 3-AB plus HBO, and group 5 received HBO. 3-Aminobenzamide (10 mg/kg per day, once daily, intraperitoneal) and saline (1 mL/kg) were started right after the induction, whereas HBO (2,8 atm pressure, BID, 90 minutes each) was started at the sixth hour. The rats were euthanized at the 54th hour, and TOSp, THSc, and Bact-Trans were studied.
Results: In treatment groups 3 and 5, Bact-Trans (P < 0.05, P < 0.05), TOSp (P < 0.05, P < 0.05), and THSc (P < 0.001, P < 0.001) were significantly lower than controls. In addition to these findings, group 4 (cotreatment) showed the most significant effect on Bact-Trans and THSc (P < 0.001, P < 0.001) and also better in TOSp (P < 0.02).
Conclusions: Poly(ADP-ribose) polymerase inhibition by 3-AB and HBO treatment alone was effective in the course of severe AP, and favorable with cotreatment because of the improved cascades of inflammatory process by different aspects.
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المشرفين على المادة: 0 (Benzamides)
0 (Enzyme Inhibitors)
0 (Poly(ADP-ribose) Polymerase Inhibitors)
5E090O0G3Z (Taurocholic Acid)
8J365YF1YH (3-aminobenzamide)
EC 2.4.2.30 (Poly(ADP-ribose) Polymerases)
تواريخ الأحداث: Date Created: 20141028 Date Completed: 20151123 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4327390
DOI: 10.1097/MPA.0000000000000240
PMID: 25347462
قاعدة البيانات: MEDLINE
الوصف
تدمد:1536-4828
DOI:10.1097/MPA.0000000000000240