دورية أكاديمية
New insights into oculodermal nevogenesis and proposal for a new iris nevus classification.
| العنوان: | New insights into oculodermal nevogenesis and proposal for a new iris nevus classification. |
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| المؤلفون: | Schwab C; Clinic of Ophthalmology, Medical University of Graz, Graz, Austria., Zalaudek I; Department of Dermatology, Medical University of Graz, Graz, Austria., Mayer C; Clinic of Ophthalmology, Medical University of Graz, Graz, Austria., Riedl R; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Wackernagel W; Clinic of Ophthalmology, Medical University of Graz, Graz, Austria., Juch H; Institute of Cell Biology, Histology and Embryology, Medical University of Graz, Graz, Austria., Aigner B; Department of Dermatology, Medical University of Graz, Graz, Austria., Brunasso AM; Department of Dermatology, Medical University of Graz, Graz, Austria., Langmann G; Clinic of Ophthalmology, Medical University of Graz, Graz, Austria., Richtig E; Department of Dermatology, Medical University of Graz, Graz, Austria. |
| المصدر: | The British journal of ophthalmology [Br J Ophthalmol] 2015 May; Vol. 99 (5), pp. 644-9. Date of Electronic Publication: 2014 Oct 30. |
| نوع المنشور: | Journal Article; Observational Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 1992- : London : BMJ Pub. Group Original Publication: 1917-Dec. 1991: London : British Medical Association |
| مواضيع طبية MeSH: | Iris Neoplasms/*classification , Nevus, Pigmented/*classification , Skin Neoplasms/*classification, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Environmental Exposure/adverse effects ; Female ; Humans ; Iris Neoplasms/etiology ; Iris Neoplasms/pathology ; Male ; Middle Aged ; Nevus, Pigmented/etiology ; Nevus, Pigmented/pathology ; Prospective Studies ; Risk Factors ; Skin Neoplasms/etiology ; Skin Neoplasms/pathology ; Sunlight/adverse effects ; Surveys and Questionnaires |
| مستخلص: | Background/aims: To gain more knowledge about presence and dermatological associations of iris nevi as well as possible pathways involved in the formation of iris nevi. Methods: We conducted a prospective, interdisciplinary observational study. Presence, morphology, topography of iris and cutaneous nevi as well as factors indicating sun-exposure were noted. Results: A total of 632 participants including 360 (57%) women were examined. Of those, 26 subjects revealed 27 iris nevi. According to the current classification, all iris nevi were judged as solitary with the majority of them (n=20; 74%) located in the lower quadrants. In six (22.2%) cases we noted a peculiar 'incomplete sectoral pattern'; these nevi were located close to the pupil, were larger and had a more elongated, triangular shape compared with those located distant from the pupil, which appeared smaller and more roundish. Notably, five of these six peculiar (incomplete sectoral) iris nevi were located on the upper half of the iris. Conclusions: Based on our findings we propose classifying iris nevi into sectoral, incomplete sectoral and solitary subtypes. Additionally, we set up a hypothetic concept of oculodermal nevogenesis suggesting a time-dependent embryogenic alteration affecting the normal melanocyte location, migration and maturation along peripheral nerve sheets. Our new concept explains well the morphology and extension of benign melanocytic proliferations in the ocular region as well as their relation to uveal melanoma. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.) |
| فهرسة مساهمة: | Keywords: Embryology and development; Epidemiology; Neoplasia |
| تواريخ الأحداث: | Date Created: 20141101 Date Completed: 20150710 Latest Revision: 20151119 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1136/bjophthalmol-2014-305849 |
| PMID: | 25359901 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-2079 |
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| DOI: | 10.1136/bjophthalmol-2014-305849 |