دورية أكاديمية
أعرض في EDS

Intensity of HLA-A2 Expression Significantly Decreased in Occult Hepatitis B Infection.

التفاصيل البيبلوغرافية
العنوان: Intensity of HLA-A2 Expression Significantly Decreased in Occult Hepatitis B Infection.
المؤلفون: Askari A; Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran., Hassanshahi GH; Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran., Ghalebi SR; Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, IR Iran., Jafarzadeh A; Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran., Mohit M; Department of Pathology, Kerman University of Medical Sciences, Kerman, IR Iran., Hajghani M; Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran., Kazemi Arababadi M; Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, IR Iran.
المصدر: Jundishapur journal of microbiology [Jundishapur J Microbiol] 2014 Jun; Vol. 7 (6), pp. e10298. Date of Electronic Publication: 2014 Jun 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Brieflands Country of Publication: Netherlands NLM ID: 101515122 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2008-3645 (Print) Linking ISSN: 20083645 NLM ISO Abbreviation: Jundishapur J Microbiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2022- : ['s-Hertogenbosch, The Netherlands] : Brieflands
Original Publication: Avaz : School of medicine, Ahvaz Jundishapur University of Medical Sciences, 2008-
مستخلص: Background: Occult hepatitis B infected (OBI) patients cannot eradicate hepatitis B virus (HBV)-DNA from their liver and peripheral blood, completely.
Objectives: The main aim of this study was to investigate the rate of HLA-A2 expression on peripheral blood mononuclear cells (PBMCs) of patients with OBI.
Materials and Methods: In this experimental study, intensity of HLA-A2 was measured on the PBMCs of 57 OBI patients and 100 HBsAg-/anti-HBc+/HBV-DNA samples were enrolled as controls; measurements were performed using the flow cytometry technique.
Results: Flow cytometric analysis indicated that 19 (33.3%) OBI patients and 28 (28%) controls expressed HLA-A2 antigen on their PBMCs. There was no significant difference between the two groups regarding the rate of individuals expressing HLA-A2 antigen. Statistical analyses showed that the intensity of HLA-A2 expression significantly decreased in OBI patients (3.58 ± 0.1) in comparison to healthy controls (4.21 ± 0.25; P < 0.001).
Conclusions: According to these results it can be concluded that decreased intensity of HLA-A2 on the PBMCs of OBI patients may lead to resistance of HBV in the patients.
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فهرسة مساهمة: Keywords: DNA; HLA-A2; Hepatitis B; Infection; Occult
تواريخ الأحداث: Date Created: 20141106 Date Completed: 20141105 Latest Revision: 20211021
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4217675
DOI: 10.5812/jjm.10298
PMID: 25371796
قاعدة البيانات: MEDLINE
الوصف
تدمد:2008-3645
DOI:10.5812/jjm.10298