دورية أكاديمية
أعرض في EDS

Menthol inhibits detrusor contractility independently of TRPM8 activation.

التفاصيل البيبلوغرافية
العنوان: Menthol inhibits detrusor contractility independently of TRPM8 activation.
المؤلفون: Ramos-Filho AC; Department of Pharmacology, University of Campinas (UNICAMP), Campinas, Brazil., Shah A; Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom., Augusto TM; Department of Anatomy, Cellular Biology, Physiology and Biophysics, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., Barbosa GO; Department of Anatomy, Cellular Biology, Physiology and Biophysics, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., Leiria LO; Department of Pharmacology, University of Campinas (UNICAMP), Campinas, Brazil., de Carvalho HF; Department of Anatomy, Cellular Biology, Physiology and Biophysics, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil., Antunes E; Department of Pharmacology, University of Campinas (UNICAMP), Campinas, Brazil., Grant AD; Wolfson Centre for Age-Related Diseases, King's College London, London, United Kingdom.
المصدر: PloS one [PLoS One] 2014 Nov 06; Vol. 9 (11), pp. e111616. Date of Electronic Publication: 2014 Nov 06 (Print Publication: 2014).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Menthol/*administration & dosage , Muscle Contraction/*drug effects , Muscle, Smooth/*physiology , TRPM Cation Channels/*metabolism , Urinary Bladder/*physiology, Animals ; Calcium Channel Blockers/pharmacology ; Calcium Chloride/metabolism ; Carbachol/pharmacology ; Cells, Cultured ; Electric Stimulation/methods ; In Vitro Techniques ; Male ; Menthol/pharmacology ; Mice ; Mice, Knockout ; Nifedipine/pharmacology ; TRPM Cation Channels/genetics ; Tetrodotoxin/pharmacology
مستخلص: Agonists such as icilin and menthol can activate the cool temperature-sensitive ion channel TRPM8. However, biological responses to menthol may occur independently of TRPM8 activation. In the rodent urinary bladder, menthol facilitates the micturition reflex but inhibits muscarinic contractions of the detrusor smooth muscle. The site(s) of TRPM8 expression in the bladder are controversial. In this study we investigated the regulation of bladder contractility in vitro by menthol. Bladder strips from wild type and TRPM8 knockout male mice (25-30 g) were dissected free and mounted in organ baths. Isometric contractions to carbachol (1 nM-30 µM), CaCl2 (1 µM to 100 mM) and electrical field stimulation (EFS; 8, 16, 32 Hz) were measured. Strips from both groups contracted similarly in response to both carbachol and EFS. Menthol (300 µM) or nifedipine (1 µM) inhibited carbachol and EFS-induced contractions in both wild type and TRPM8 knockout bladder strips. Incubation with the sodium channel blocker tetrodotoxin (1 µM), replacement of extracellular sodium with the impermeant cation N-Methyl-D-Glucamine, incubation with a cocktail of potassium channel inhibitors (100 nM charybdotoxin, 1 µM apamin, 10 µM glibenclamide and 1 µM tetraethylammonium) or removal of the urothelium did not affect the inhibitory actions of menthol. Contraction to CaCl2 was markedly inhibited by either menthol or nifedipine. In cultured bladder smooth muscle cells, menthol or nifedipine abrogated the carbachol or KCl-induced increases in [Ca2+]i. Intravesical administration of menthol increased voiding frequency while decreasing peak voiding pressure. We conclude that menthol inhibits muscarinic bladder contractions through blockade of L-type calcium channels, independently of TRPM8 activation.
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المشرفين على المادة: 0 (Calcium Channel Blockers)
0 (TRPM Cation Channels)
0 (TRPM8 protein, mouse)
1490-04-6 (Menthol)
4368-28-9 (Tetrodotoxin)
8Y164V895Y (Carbachol)
I9ZF7L6G2L (Nifedipine)
M4I0D6VV5M (Calcium Chloride)
تواريخ الأحداث: Date Created: 20141107 Date Completed: 20150714 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4222941
DOI: 10.1371/journal.pone.0111616
PMID: 25375115
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0111616