دورية أكاديمية
أعرض في EDS

Sulfated chitosan oligosaccharides suppress LPS-induced NO production via JNK and NF-κB inactivation.

التفاصيل البيبلوغرافية
العنوان: Sulfated chitosan oligosaccharides suppress LPS-induced NO production via JNK and NF-κB inactivation.
المؤلفون: Kim JH; Department of Biotechnology, Konkuk University, Chungju 380-701, Korea., Kim YS; Department of Biotechnology, Konkuk University, Chungju 380-701, Korea., Hwang JW; Department of Biotechnology, Konkuk University, Chungju 380-701, Korea., Han YK; Department of Biotechnology, Konkuk University, Chungju 380-701, Korea., Lee JS; Industry-Academic Cooperation Foundation, Jeju National University, Jeju 690-756, Korea., Kim SK; Specialized Graduate School & Technology Convergence, Department of Marine-Bio Convergence Science, Pukyong National University, Busan 608-737, Korea., Jeon YJ; School of Marine Biomedical Sciences, Jeju National University, Jeju 690-756, Korea., Moon SH; Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Korea., Jeon BT; Korea Nokyong Research Center, Konkuk University, Chungju 380-701, Korea., Bahk YY; Department of Biotechnology, Konkuk University, Chungju 380-701, Korea. byoung1@kku.ac.kr., Park PJ; Department of Biotechnology, Konkuk University, Chungju 380-701, Korea. parkpj@kku.ac.kr.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2014 Nov 07; Vol. 19 (11), pp. 18232-47. Date of Electronic Publication: 2014 Nov 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Chitosan/*chemistry , Lipopolysaccharides/*toxicity , MAP Kinase Kinase 4/*metabolism , Macrophages/*metabolism , Nitric Oxide/*metabolism , Oligosaccharides/*pharmacology , Transcription Factor RelA/*metabolism, Animals ; Cell Line ; Interleukin-6/metabolism ; MAP Kinase Signaling System/drug effects ; Macrophages/pathology ; Mice ; Nitric Oxide Synthase Type II/biosynthesis ; Oligosaccharides/chemistry ; Tumor Necrosis Factor-alpha/metabolism
مستخلص: Various biological effects have been reported for sulfated chitosan oligosaccharides, but the molecular mechanisms of action of their anti-inflammatory effects are still unknown. This study aimed to evaluate the anti-inflammatory effects of sulfated chitosan oligosaccharides and to elucidate the possible mechanisms of action. The results showed that pretreated low molecular weight sulfated chitosan oligosaccharides inhibited the production of nitric oxide (NO) and inflammatory cytokines such as IL-6 and TNF-α in lipopolysaccharide (LPS)-activated RAW264.7 cells. The sulfated chitosan oligosaccharides also suppressed inducible nitric oxide synthase (iNOS), phosphorylation of JNK and translocation of p65, a subunit of NF-κB, into the nucleus by inhibiting degradation of IκB-α. Our investigation suggests sulfated chitosan oligosaccharides inhibit IL-6/TNF-α in LPS-induced macrophages, regulated by mitogen-activated protein kinases (MAPKs) pathways dependent on NF-κB activation.
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المشرفين على المادة: 0 (Interleukin-6)
0 (Lipopolysaccharides)
0 (Oligosaccharides)
0 (Rela protein, mouse)
0 (Transcription Factor RelA)
0 (Tumor Necrosis Factor-alpha)
31C4KY9ESH (Nitric Oxide)
9012-76-4 (Chitosan)
EC 1.14.13.39 (Nitric Oxide Synthase Type II)
EC 1.14.13.39 (Nos2 protein, mouse)
EC 2.7.12.2 (MAP Kinase Kinase 4)
تواريخ الأحداث: Date Created: 20141112 Date Completed: 20151005 Latest Revision: 20200225
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6271491
DOI: 10.3390/molecules191118232
PMID: 25387351
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules191118232