دورية أكاديمية
Potential role of granulocyte-monocyte colony-stimulating factor in the progression of intracranial aneurysms.
العنوان: | Potential role of granulocyte-monocyte colony-stimulating factor in the progression of intracranial aneurysms. |
---|---|
المؤلفون: | Chalouhi N; 1 Department of Neurosurgery, Jefferson Hospital for Neuroscience, Thomas Jefferson University , Philadelphia, Pennsylvania., Theofanis T, Starke RM, Zanaty M, Jabbour P, Dooley SA, Hasan D |
المصدر: | DNA and cell biology [DNA Cell Biol] 2015 Jan; Vol. 34 (1), pp. 78-81. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 9004522 Publication Model: Print Cited Medium: Internet ISSN: 1557-7430 (Electronic) Linking ISSN: 10445498 NLM ISO Abbreviation: DNA Cell Biol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: [New York, NY] : Mary Ann Liebert, [c1990- |
مواضيع طبية MeSH: | Granulocyte Colony-Stimulating Factor/*blood , Intracranial Aneurysm/*blood, Aged ; Disease Progression ; Female ; Humans ; Intracranial Aneurysm/pathology ; Male ; Middle Aged |
مستخلص: | Macrophages play a central role in the inflammatory response leading to aneurysm formation, progression, and rupture. The purpose of this study was to determine whether granulocyte-monocyte colony-stimulating factor (GM-CSF) plays a role in the progression of human intracranial aneurysms. Specifically, we investigated whether there was a correlation between the aneurysm size and the concentration of GM-CSF in the lumen of intracranial aneurysms. The concentrations of GM-CSF in blood samples drawn from the lumen of 15 human unruptured saccular intracranial aneurysms of 14 consecutive patients were compared. The aneurysm size was 10.3±9 mm on average. The mean plasma concentration of GM-CSF was 27.9±3.1 pg/mL in the lumen of intracranial aneurysms. The mean plasma concentration of GM-CSF was significantly higher in aneurysms larger than 7 mm (30.1±2.8 pg/mL) compared with aneurysms smaller than 7 mm (26.4±2.4 pg/mL; p=0.02). There was a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF (Spearman's rho=0.55; p=0.04). There is a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF in aneurysm lumens. This suggests that GM-CSF, through its stimulatory function on macrophages, may promote aneurysm progression and may be a possible therapeutic target. |
References: | Nat Rev Immunol. 2008 Jul;8(7):533-44. (PMID: 18551128) Stroke. 2007 Jan;38(1):162-9. (PMID: 17122420) N Engl J Med. 1998 Dec 10;339(24):1725-33. (PMID: 9867550) Cancer Res. 1995 Nov 15;55(22):5161-3. (PMID: 7585565) Trends Immunol. 2002 Aug;23(8):403-8. (PMID: 12133803) Cytokine. 2000 Jul;12(7):1151-5. (PMID: 10880267) World Neurosurg. 2014 Feb;81(2):206-8. (PMID: 24355516) Stroke. 2013 Dec;44(12):3613-22. (PMID: 24130141) PLoS One. 2013;8(8):e71954. (PMID: 23967268) Crit Rev Immunol. 2005;25(5):405-28. (PMID: 16167889) Growth Factors. 2004 Dec;22(4):225-31. (PMID: 15621725) Ann Rheum Dis. 2013 Sep 1;72(9):1445-52. (PMID: 23234647) Curr Neurovasc Res. 2013 Aug;10(3):247-55. (PMID: 23713738) Stroke. 2012 Dec;43(12):3258-65. (PMID: 23138441) J Cereb Blood Flow Metab. 2012 Sep;32(9):1659-76. (PMID: 22781330) Stroke. 2011 Jan;42(1):173-8. (PMID: 21106959) Stroke. 2009 Mar;40(3):942-51. (PMID: 19164781) Ann Rheum Dis. 2015 Jun;74(6):1058-64. (PMID: 24534756) |
المشرفين على المادة: | 143011-72-7 (Granulocyte Colony-Stimulating Factor) |
تواريخ الأحداث: | Date Created: 20141113 Date Completed: 20150324 Latest Revision: 20181113 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC4281873 |
DOI: | 10.1089/dna.2014.2618 |
PMID: | 25389911 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1557-7430 |
---|---|
DOI: | 10.1089/dna.2014.2618 |