دورية أكاديمية
Potential role of granulocyte-monocyte colony-stimulating factor in the progression of intracranial aneurysms.
| العنوان: | Potential role of granulocyte-monocyte colony-stimulating factor in the progression of intracranial aneurysms. |
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| المؤلفون: | Chalouhi N; 1 Department of Neurosurgery, Jefferson Hospital for Neuroscience, Thomas Jefferson University , Philadelphia, Pennsylvania., Theofanis T, Starke RM, Zanaty M, Jabbour P, Dooley SA, Hasan D |
| المصدر: | DNA and cell biology [DNA Cell Biol] 2015 Jan; Vol. 34 (1), pp. 78-81. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 9004522 Publication Model: Print Cited Medium: Internet ISSN: 1557-7430 (Electronic) Linking ISSN: 10445498 NLM ISO Abbreviation: DNA Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: [New York, NY] : Mary Ann Liebert, [c1990- |
| مواضيع طبية MeSH: | Granulocyte Colony-Stimulating Factor/*blood , Intracranial Aneurysm/*blood, Aged ; Disease Progression ; Female ; Humans ; Intracranial Aneurysm/pathology ; Male ; Middle Aged |
| مستخلص: | Macrophages play a central role in the inflammatory response leading to aneurysm formation, progression, and rupture. The purpose of this study was to determine whether granulocyte-monocyte colony-stimulating factor (GM-CSF) plays a role in the progression of human intracranial aneurysms. Specifically, we investigated whether there was a correlation between the aneurysm size and the concentration of GM-CSF in the lumen of intracranial aneurysms. The concentrations of GM-CSF in blood samples drawn from the lumen of 15 human unruptured saccular intracranial aneurysms of 14 consecutive patients were compared. The aneurysm size was 10.3±9 mm on average. The mean plasma concentration of GM-CSF was 27.9±3.1 pg/mL in the lumen of intracranial aneurysms. The mean plasma concentration of GM-CSF was significantly higher in aneurysms larger than 7 mm (30.1±2.8 pg/mL) compared with aneurysms smaller than 7 mm (26.4±2.4 pg/mL; p=0.02). There was a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF (Spearman's rho=0.55; p=0.04). There is a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF in aneurysm lumens. This suggests that GM-CSF, through its stimulatory function on macrophages, may promote aneurysm progression and may be a possible therapeutic target. |
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| المشرفين على المادة: | 143011-72-7 (Granulocyte Colony-Stimulating Factor) |
| تواريخ الأحداث: | Date Created: 20141113 Date Completed: 20150324 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4281873 |
| DOI: | 10.1089/dna.2014.2618 |
| PMID: | 25389911 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-7430 |
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| DOI: | 10.1089/dna.2014.2618 |