دورية أكاديمية
Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy.
| العنوان: | Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy. |
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| المؤلفون: | Bongers KS; Departments of Internal Medicine and Molecular Physiology and Biophysics and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine., Fox DK; Departments of Internal Medicine and Molecular Physiology and Biophysics and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine., Kunkel SD; Departments of Internal Medicine and Molecular Physiology and Biophysics and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine., Stebounova LV; College of Pharmacy, Roy J. and Lucille A. Carver College of Medicine., Murry DJ; College of Pharmacy, Roy J. and Lucille A. Carver College of Medicine., Pufall MA; Department of Biochemistry, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, Iowa, and., Ebert SM; Departments of Internal Medicine and Molecular Physiology and Biophysics and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine., Dyle MC; Departments of Internal Medicine and Molecular Physiology and Biophysics and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine., Bullard SA; Departments of Internal Medicine and Molecular Physiology and Biophysics and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa., Dierdorff JM; Departments of Internal Medicine and Molecular Physiology and Biophysics and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine., Adams CM; Departments of Internal Medicine and Molecular Physiology and Biophysics and Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, Iowa City Veterans Affairs Medical Center, Iowa City, Iowa christopher-adams@uiowa.edu. |
| المصدر: | American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2015 Jan 15; Vol. 308 (2), pp. E144-58. Date of Electronic Publication: 2014 Nov 18. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD. : American Physiological Society |
| مواضيع طبية MeSH: | GTP Phosphohydrolases/*metabolism , Gene Expression Regulation, Enzymologic/*physiology , Muscle Fibers, Skeletal/*metabolism , Muscular Atrophy/*metabolism , Myogenin/*metabolism , Oxidoreductases Acting on CH-NH Group Donors/*metabolism, Animals ; Fasting/physiology ; GTP Phosphohydrolases/genetics ; Immunoblotting ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Denervation ; Muscle Fibers, Skeletal/enzymology ; Muscular Atrophy/enzymology ; Muscular Atrophy/genetics ; Myogenin/genetics ; Oxidoreductases Acting on CH-NH Group Donors/genetics ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Restraint, Physical/physiology ; Polyamine Oxidase |
| مستخلص: | Skeletal muscle atrophy is a common and debilitating condition that remains poorly understood at the molecular level. To better understand the mechanisms of muscle atrophy, we used mouse models to search for a skeletal muscle protein that helps to maintain muscle mass and is specifically lost during muscle atrophy. We discovered that diverse causes of muscle atrophy (limb immobilization, fasting, muscle denervation, and aging) strongly reduced expression of the enzyme spermine oxidase. Importantly, a reduction in spermine oxidase was sufficient to induce muscle fiber atrophy. Conversely, forced expression of spermine oxidase increased muscle fiber size in multiple models of muscle atrophy (immobilization, fasting, and denervation). Interestingly, the reduction of spermine oxidase during muscle atrophy was mediated by p21, a protein that is highly induced during muscle atrophy and actively promotes muscle atrophy. In addition, we found that spermine oxidase decreased skeletal muscle mRNAs that promote muscle atrophy (e.g., myogenin) and increased mRNAs that help to maintain muscle mass (e.g., mitofusin-2). Thus, in healthy skeletal muscle, a relatively low level of p21 permits expression of spermine oxidase, which helps to maintain basal muscle gene expression and fiber size; conversely, during conditions that cause muscle atrophy, p21 expression rises, leading to reduced spermine oxidase expression, disruption of basal muscle gene expression, and muscle fiber atrophy. Collectively, these results identify spermine oxidase as an important positive regulator of muscle gene expression and fiber size, and elucidate p21-mediated repression of spermine oxidase as a key step in the pathogenesis of skeletal muscle atrophy. |
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| معلومات مُعتمدة: | I01 BX000976 United States BX BLRD VA; F30 AG-04330401 United States AG NIA NIH HHS; AR-059115-04 United States AR NIAMS NIH HHS; T32 DK007762 United States DK NIDDK NIH HHS; 5T32 GM-007337 United States GM NIGMS NIH HHS; F30 AG-04496401 United States AG NIA NIH HHS; 1F31 AG-04603801 United States AG NIA NIH HHS; T32 GM007337 United States GM NIGMS NIH HHS; I01 RX001477 United States RX RRD VA; R01 AR059115 United States AR NIAMS NIH HHS; F30 AG044964 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: p21; polyamine; skeletal muscle; skeletal muscle atrophy; spermine oxidase |
| المشرفين على المادة: | 0 (Myogenin) 0 (RNA, Messenger) EC 1.5.- (Oxidoreductases Acting on CH-NH Group Donors) EC 3.6.1.- (GTP Phosphohydrolases) EC 3.6.1.- (Mfn2 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20141120 Date Completed: 20150416 Latest Revision: 20231213 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC4297781 |
| DOI: | 10.1152/ajpendo.00472.2014 |
| PMID: | 25406264 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1555 |
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| DOI: | 10.1152/ajpendo.00472.2014 |