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Neonatal sensitization to ethanol-induced breathing disruptions as a function of late prenatal exposure to the drug in the rat: modulatory effects of ethanol's chemosensory cues.

التفاصيل البيبلوغرافية
العنوان: Neonatal sensitization to ethanol-induced breathing disruptions as a function of late prenatal exposure to the drug in the rat: modulatory effects of ethanol's chemosensory cues.
المؤلفون: Cullere M; Instituto de Investigación Médica Mercedes y Martin Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Argentina., Macchione AF; Instituto de Investigación Médica Mercedes y Martin Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Argentina., Haymal B; Instituto de Investigación Médica Mercedes y Martin Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Argentina., Paradelo M; Unidad Hospitalaria San Roque, Universidad Nacional de Córdoba, Argentina., Langer MD; Hospital Aeronáutico, Cordoba, Argentina., Spear NE; Center for Development and Behavioral Neuroscience, Binghamton University, Binghamton, NY, USA. Electronic address: nspear@binghamton.edu., Molina JC; Instituto de Investigación Médica Mercedes y Martin Ferreyra, INIMEC-CONICET-Universidad Nacional de Córdoba, Argentina; Center for Development and Behavioral Neuroscience, Binghamton University, Binghamton, NY, USA; Facultad de Psicología, Universidad Nacional de Córdoba, Argentina. Electronic address: jmolina@immf.uncor.edu.
المصدر: Physiology & behavior [Physiol Behav] 2015 Feb; Vol. 139, pp. 412-22. Date of Electronic Publication: 2014 Oct 30.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE
أسماء مطبوعة: Publication: New York NY : Elsevier Science
Original Publication: Oxford, Eng., Long Island City, Pergamon Press.
مواضيع طبية MeSH: Prenatal Exposure Delayed Effects*, Central Nervous System Depressants/*toxicity , Ethanol/*toxicity , Olfactory Perception/*drug effects , Olfactory Perception/*physiology , Respiration/*drug effects, Animals ; Animals, Newborn ; Apnea/physiopathology ; Central Nervous System Depressants/pharmacokinetics ; Cues ; Dose-Response Relationship, Drug ; Ethanol/pharmacokinetics ; Female ; Lung/drug effects ; Lung/growth & development ; Lung/physiopathology ; Male ; Odorants ; Plethysmography, Whole Body ; Pregnancy ; Rats, Wistar ; Time Factors
مستخلص: Preclinical and clinical studies have systematically demonstrated abrupt changes in fetal respiratory patterns when the unborn organism is exposed to the effects of maternal ethanol intoxication. In subprimates, chronic exposure to this drug during gestation and infancy results in marked alterations of the plasticity of the respiratory network. These alterations are manifested in terms of an early incapability to overcome deleterious effects of hypoxic events as well as in terms of sensitization to ethanol's depressant effects upon breathing patterns. It has also been demonstrated that near term rat fetuses process ethanol's chemosensory cues when the drug contaminates the amniotic fluid and that associative learning processes occur due to the temporal contiguity existing between these cues and different ethanol-related physiological effects. In the present study during the course of late gestation (gestational days 17-20), pregnant rats were intragastrically administered with either 0.0 or 2.0 g/kg ethanol. Seven-day-old pups derived of these dams were evaluated in terms of respiration rates (breaths/min) and apneas when subjected to different experimental conditions. These conditions were defined by postnatal exposure to the drug (intragastric administrations of either 0.0, 0.5, 1.0 or 2.0 g/kg ethanol), postadministration time of evaluation (5-10 or 30-35 min) and olfactory context at test (no explicit ambient odor or ethanol ambient odor). The results, obtained via whole body plethysmography, indicated that brief prenatal experience with the drug sensitized the organisms to ethanol's depressant effects particularly when employing the higher ethanol doses. In turn, presence of ethanol odor at test potentiated the above mentioned respiratory alterations. Prenatal treatment with ethanol was not found to alter pharmacokinetic profiles resulting from postnatal exposure to the drug or to affect different morphometric parameters related with lung development. These results indicate that even brief exposure to the drug during late gestation is sufficient to sensitize the organism to later disruptive effects of the drug upon breathing responsiveness. These deficits are potentiated through the re-exposure to the olfactory context perceived in utero which is known to be associated with ethanol's unconditioned effects. As a function of these observations it is possible to suggest a critical role of fetal sensory and learning capabilities in terms of modulating later ethanol-related breathing disruptions.
(Copyright © 2014. Published by Elsevier Inc.)
معلومات مُعتمدة: AA013098 United States AA NIAAA NIH HHS; AA015992 United States AA NIAAA NIH HHS; AA11960 United States AA NIAAA NIH HHS; MH035219 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: Breathing disruption; Fetal ethanol intoxication; Late gestation; Olfactory stimulation; Sensitization
المشرفين على المادة: 0 (Central Nervous System Depressants)
3K9958V90M (Ethanol)
تواريخ الأحداث: Date Created: 20141203 Date Completed: 20150831 Latest Revision: 20161125
رمز التحديث: 20231215
DOI: 10.1016/j.physbeh.2014.10.017
PMID: 25447327
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-507X
DOI:10.1016/j.physbeh.2014.10.017