دورية أكاديمية
أعرض في EDS

Dermatoglyphics in relation to brain volumes in twins concordant and discordant for bipolar disorder.

التفاصيل البيبلوغرافية
العنوان: Dermatoglyphics in relation to brain volumes in twins concordant and discordant for bipolar disorder.
المؤلفون: Vonk R; Reinier van Arkel Groep, PO Box 70058, 5201 DZ, ׳s-Hertogenbosch, The Netherlands. Electronic address: r.vonk@RvAgroep.nl., van der Schot AC; Alzheimer Nederland, Amersfoort, The Netherlands., van Baal GC; Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, Afdeling, Biostatistiek, Utrecht, The Netherlands., van Oel CJ; Department of Real Estate & Housing, Faculty of Architecture, Delft University of Technology, Delft, The Netherlands., Nolen WA; University Medical Center Groningen, Groningen, The Netherlands., Kahn RS; Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, Utrecht, The Netherlands.
المصدر: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2014 Dec; Vol. 24 (12), pp. 1885-95. Date of Electronic Publication: 2014 Oct 08.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Twin Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier, c1990-
مواضيع طبية MeSH: Dermatoglyphics*, Bipolar Disorder/*genetics , Bipolar Disorder/*pathology , Brain/*pathology , Twins, Dizygotic/*genetics , Twins, Monozygotic/*genetics, Adolescent ; Adult ; Bipolar Disorder/psychology ; Case-Control Studies ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuroimaging ; Organ Size ; Twins, Dizygotic/psychology ; Twins, Monozygotic/psychology ; Young Adult
مستخلص: Palmar and finger dermatoglyphics are formed between the 10th and the 17th weeks of gestation and their morphology can be influenced by genetic or environmental factors, interfering with normal intrauterine development. As both the skin and the brain develop from the same embryonal ectoderm, dermatoglyphic alterations may be informative for early abnormal neurodevelopmental processes in the brain. We investigated whether dermatoglyphic alterations are related to structural brain abnormalities in bipolar disorder and to what extent they are of a genetic and of an environmental origin. Dermatoglyphics and volumetric data from structural MRI were obtained in 53 twin pairs concordant or discordant for bipolar disorder and 51 healthy matched control twin pairs. Structural equation modeling was used. Bipolar disorder was significantly positively associated with palmar a-b ridge count (ABRC), indicating higher ABRC in bipolar patients (rph=.17 (CI .04-.30)). Common genes appear to be involved because the genetic correlation with ABRC was significant (rph-A=.21 (CI .05-.36). Irrespective of disease, ABRC showed a genetically mediated association with brain volume, indicated by a significant genetic correlation rph-A of respectively -.36 (CI -.52 to -.22) for total brain, -.34 (CI -.51 to -.16) total cortical volume, -.27 (CI -.43 to -.08) cortical gray matter and -.23 (CI -.41 to -.04) cortical white matter. In conclusion, a genetically determined abnormal development of the foetal ectoderm between the 10th and 15th week of gestation appears related to smaller brain volumes in (subjects at risk for) bipolar disorder.
(Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.)
فهرسة مساهمة: Keywords: Bipolar disorder; Dermatoglyphics; Genetics; Neurodevelopment; Twins
تواريخ الأحداث: Date Created: 20141203 Date Completed: 20151009 Latest Revision: 20141208
رمز التحديث: 20240628
DOI: 10.1016/j.euroneuro.2014.09.010
PMID: 25451699
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7862
DOI:10.1016/j.euroneuro.2014.09.010