دورية أكاديمية
The plasmacytoid dendritic cell as the Swiss army knife of the immune system: molecular regulation of its multifaceted functions.
| العنوان: | The plasmacytoid dendritic cell as the Swiss army knife of the immune system: molecular regulation of its multifaceted functions. |
|---|---|
| المؤلفون: | Karrich JJ; Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands;, Jachimowski LC; Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands;, Uittenbogaart CH; Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095; and Department of Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095., Blom B; Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; b.blom@amc.uva.nl. |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 Dec 15; Vol. 193 (12), pp. 5772-8. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Dendritic Cells/*immunology , Dendritic Cells/*metabolism , Immune System/*physiology, Animals ; Antigens/immunology ; Antigens/metabolism ; Autoimmune Diseases/immunology ; Autoimmune Diseases/metabolism ; Cytotoxicity, Immunologic ; Humans ; Immune Tolerance ; Immunomodulation ; Signal Transduction ; Toll-Like Receptors/metabolism |
| مستخلص: | Plasmacytoid dendritic cells (pDC) have been regarded as the "professional type I IFN-producing cells" of the immune system following viral recognition that relies on the expression of TLR7 and TLR9. Furthermore, pDC link the innate and adaptive immune systems via cytokine production and Ag presentation. More recently, their ability to induce tolerance and cytotoxicity has been added to their "immune skills." Such a broad range of actions, resembling the diverse functional features of a Swiss army knife, requires strong and prompt molecular regulation to prevent detrimental effects, including autoimmune pathogenesis or tumor escape. Over the last decades, we and other investigators have started to unravel some aspects of the signaling pathways that regulate the various functions of human pDC. In this article, we review aspects of the molecular regulatory mechanisms to control pDC function in light of their multifaceted roles during immunity, autoimmunity, and cancer. (Copyright © 2014 by The American Association of Immunologists, Inc.) |
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| معلومات مُعتمدة: | P30 AI028697 United States AI NIAID NIH HHS; R01 AI080564 United States AI NIAID NIH HHS; AI080564 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Antigens) 0 (Toll-Like Receptors) |
| تواريخ الأحداث: | Date Created: 20141207 Date Completed: 20150311 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4258904 |
| DOI: | 10.4049/jimmunol.1401541 |
| PMID: | 25480956 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-6606 |
|---|---|
| DOI: | 10.4049/jimmunol.1401541 |