دورية أكاديمية
Serum adiponectin, leptin, and interleukin 6 levels as adipocytokines in children with febrile seizures: The role of adipose tissue in febrile seizures.
| العنوان: | Serum adiponectin, leptin, and interleukin 6 levels as adipocytokines in children with febrile seizures: The role of adipose tissue in febrile seizures. |
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| المؤلفون: | Güven AS; Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey asamiguven@hotmail.com., Icagasioglu FD; Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey., Duksal F; Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey., Sancakdar E; Department of Biochemistry, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey., Alaygut D; Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey., Uysal EB; Department of Microbiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey., Akkar I; Department of Pediatrics, Sivas Government Hospital, Sivas, Turkey., Oflaz MB; Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey., Kaya A; Department of Pediatrics, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. |
| المصدر: | Human & experimental toxicology [Hum Exp Toxicol] 2015 Sep; Vol. 34 (9), pp. 878-83. Date of Electronic Publication: 2014 Dec 09. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: England NLM ID: 9004560 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0903 (Electronic) Linking ISSN: 09603271 NLM ISO Abbreviation: Hum Exp Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : SAGE Publications Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press, c1990- |
| مواضيع طبية MeSH: | Adipokines/*blood , Adiponectin/*blood , Adipose Tissue/*pathology , Interleukin-6/*blood , Leptin/*blood , Seizures, Febrile/*metabolism , Seizures, Febrile/*pathology, C-Reactive Protein/metabolism ; Child, Preschool ; Female ; Hemoglobins/metabolism ; Humans ; Infant ; Leukocyte Count ; Male ; Prospective Studies |
| مستخلص: | Proinflammatory and anti-inflammatory cytokines have an important role in the pathogenesis of febrile seizures (FS). Adipocytokines like interleukin 6 (IL-6), leptin, and adiponectin released from adipose tissue play a role in inflammation. This study aimed to assess the probable role of adipose tissue in children with FS. We measured serum IL-6, leptin, and adiponectin levels and evaluated clinical and laboratory findings in children with FS (n = 32) and compared the results with the values of children of the same age with febrile illness without seizures (febrile control, FC; n = 26) and healthy control group (HC; n = 29). The serum levels of white blood cells, C-reactive protein, IL-6, leptin, and adiponectin were found to be significantly higher, while serum hemoglobin (Hb) levels were found to be significantly lower in FS and FC groups than in the HC group (p < 0.001). When we compared the FS with the FC group, the serum Hb levels were significantly lower in the FS group than those in the FC group (p = 0.001). There was no significant difference between the FS and FC group with regard to the serum levels of these adipocytokines (p > 0.05). Our data showed that elevated levels of these adipocytokines as acute phase reactants in FS and FC groups did not contribute to the development of FS. (© The Author(s) 2014.) |
| فهرسة مساهمة: | Keywords: Adipocytokines; IL-6; adiponectin; febrile seizures; leptin |
| المشرفين على المادة: | 0 (ADIPOQ protein, human) 0 (Adipokines) 0 (Adiponectin) 0 (Hemoglobins) 0 (IL6 protein, human) 0 (Interleukin-6) 0 (Leptin) 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20141216 Date Completed: 20160516 Latest Revision: 20150819 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1177/0960327114561662 |
| PMID: | 25504688 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1477-0903 |
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| DOI: | 10.1177/0960327114561662 |