دورية أكاديمية
Diagnosis of hepatic glycogenosis in poorly controlled type 1 diabetes mellitus.
| العنوان: | Diagnosis of hepatic glycogenosis in poorly controlled type 1 diabetes mellitus. |
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| المؤلفون: | Giordano S; Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, 'Sapienza' University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy., Martocchia A; Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, 'Sapienza' University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy., Toussan L; Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, 'Sapienza' University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy., Stefanelli M; Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, 'Sapienza' University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy., Pastore F; Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, 'Sapienza' University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy., Devito A; Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, 'Sapienza' University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy., Risicato MG; Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, 'Sapienza' University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy., Ruco L; Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, 'Sapienza' University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy., Falaschi P; Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, 'Sapienza' University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy. |
| المصدر: | World journal of diabetes [World J Diabetes] 2014 Dec 15; Vol. 5 (6), pp. 882-8. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101547524 Publication Model: Print Cited Medium: Print ISSN: 1948-9358 (Print) Linking ISSN: 19489358 NLM ISO Abbreviation: World J Diabetes Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014-: Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing, China : Beijing Baishideng BioMed Scientifc Company |
| مستخلص: | Hepatic glycogenosis (HG) in type 1 diabetes is a underrecognized complication. Mauriac firstly described the syndrome characterized by hepatomegaly with altered liver enzymes, growth impairment, delay puberty and Cushingoid features, during childhood. HG in adulthood is characterized by the liver disorder (with circulating aminotransferase increase) in the presence of poor glycemic control (elevation of glycated hemoglobin, HbA1c levels). The advances in the comprehension of the metabolic pathways driving to the hepatic glycogen deposition point out the role of glucose transporters and insulin mediated activations of glucokinase and glycogen synthase, with inhibition of glucose-6-phosphatase. The differential diagnosis of HG consists in the exclusion of causes of liver damage (infectious, metabolic, obstructive and autoimmune disease). The imaging study (ultrasonography and/or radiological examinations) gives information about the liver alterations (hepatomegaly), but the diagnosis needs to be confirmed by the liver biopsy. The main treatment of HG is the amelioration of glycemic control that is usually accompanied by the reversal of the liver disorder. In selected cases, more aggressive treatment options (transplantation) have been successfully reported. |
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| فهرسة مساهمة: | Keywords: Glucokinase; Glucose transporters; Glucose-6-phosphatase; Glycogen; Glycogen synthase; Hepatic glycogenosis; Hepatomegaly; Insulin; Type 1 diabetes mellitus |
| تواريخ الأحداث: | Date Created: 20141217 Date Completed: 20141216 Latest Revision: 20220410 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC4265875 |
| DOI: | 10.4239/wjd.v5.i6.882 |
| PMID: | 25512791 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1948-9358 |
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| DOI: | 10.4239/wjd.v5.i6.882 |