دورية أكاديمية
أعرض في EDS

Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat.

التفاصيل البيبلوغرافية
العنوان: Potential protective effect of Tualang honey on BPA-induced ovarian toxicity in prepubertal rat.
المؤلفون: Zaid SS, Othman S, Kassim NM; Department of Anatomy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. normadiah_mk@um.edu.my.
المصدر: BMC complementary and alternative medicine [BMC Complement Altern Med] 2014 Dec 17; Vol. 14, pp. 509. Date of Electronic Publication: 2014 Dec 17.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088661 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6882 (Electronic) Linking ISSN: 14726882 NLM ISO Abbreviation: BMC Complement Altern Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-2019]
مواضيع طبية MeSH: Apitherapy* , Honey*, Benzhydryl Compounds/*adverse effects , Estrous Cycle/*drug effects , Ovarian Diseases/*drug therapy , Ovarian Follicle/*drug effects , Phenols/*adverse effects, Animals ; Body Weight/drug effects ; Female ; Ovarian Diseases/chemically induced ; Ovarian Diseases/pathology ; Ovarian Follicle/pathology ; Rats, Sprague-Dawley ; Sexual Development
مستخلص: Background: To investigate the potential protective effects of Tualang honey against the toxicity effects induced by Bisphenol A (BPA) on pubertal development of ovaries.
Methods: This study was conducted on pre-pubertal female Sprague Dawley rats. Animals were divided into four groups (n = 8 in each group). Group I was administered with vehicle 0.2 ml of corn oil (Sigma-Aldrich, USA) using oral gavage daily for six weeks; these animals served as negative control (CO group), Group II was administered with BPA suspended in corn oil at 10 mg/kg body weight and served as positive control (PC group), Group III was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of BPA at 10 mg/kg (TH group) while Group IV was administered with 200 mg/kg body weight of Tualang honey 30 min before the administration of corn oil (THC group). Body weight of all animals were monitored weekly.
Results: The BPA-exposed animals exhibited disruption of their estrus cycle, while those animals treated with BPA together with Tualang honey, exhibited an improvement in percentage of normal estrous cycle. Their ovaries had lower numbers of atretic follicles compared to the PC group but higher than the CO group.
Conclusions: Tualang honey has a potential role in reducing BPA-induced ovarian toxicity by reducing the morphological abnormalities of the ovarian follicles and improving the normal estrous cycle.
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المشرفين على المادة: 0 (Benzhydryl Compounds)
0 (Phenols)
MLT3645I99 (bisphenol A)
تواريخ الأحداث: Date Created: 20141219 Date Completed: 20150904 Latest Revision: 20220409
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4301897
DOI: 10.1186/1472-6882-14-509
PMID: 25519484
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6882
DOI:10.1186/1472-6882-14-509