دورية أكاديمية
Development of venous thromboembolism (VTE) in patients undergoing surgery for brain tumors: results from a single center over a 10 year period.
| العنوان: | Development of venous thromboembolism (VTE) in patients undergoing surgery for brain tumors: results from a single center over a 10 year period. |
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| المؤلفون: | Smith TR; Department of Neurosurgery, Brigham and Women's Hospital, 15 Francis Street-PBB3, Boston, MA 02115, USA. Electronic address: trsmith@partners.org., Nanney AD 3rd; Department of Neurosurgery, Northwestern University, Chicago, IL, USA., Lall RR; Department of Neurosurgery, Northwestern University, Chicago, IL, USA., Graham RB; Department of Neurosurgery, Northwestern University, Chicago, IL, USA., McClendon J Jr; Department of Neurosurgery, Northwestern University, Chicago, IL, USA., Lall RR; Department of Neurosurgery, Northwestern University, Chicago, IL, USA., Adel JG; Department of Neurosurgery, Northwestern University, Chicago, IL, USA., Zakarija A; Department of Hematology/Oncology, Northwestern University, Chicago, IL, USA., Cote DJ; Department of Neurosurgery, Brigham and Women's Hospital, 15 Francis Street-PBB3, Boston, MA 02115, USA., Chandler JP; Department of Neurosurgery, Northwestern University, Chicago, IL, USA. |
| المصدر: | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2015 Mar; Vol. 22 (3), pp. 519-25. Date of Electronic Publication: 2014 Dec 18. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 9433352 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2653 (Electronic) Linking ISSN: 09675868 NLM ISO Abbreviation: J Clin Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Edinburgh : Churchill Livingstone Original Publication: Melbourne, Vic., Australia : Churchill Livingstone, c1994- |
| مواضيع طبية MeSH: | Brain Neoplasms/*surgery , Craniotomy/*adverse effects , Pulmonary Embolism/*etiology , Venous Thromboembolism/*etiology , Venous Thrombosis/*etiology, Adult ; Aged ; Anticoagulants/therapeutic use ; Female ; Humans ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Odds Ratio ; Predictive Value of Tests ; Pulmonary Embolism/prevention & control ; Retrospective Studies ; Risk Factors ; Venous Thromboembolism/prevention & control ; Venous Thrombosis/prevention & control |
| مستخلص: | Patients who undergo craniotomy for brain neoplasms have a high risk of developing venous thromboembolism (VTE), including deep vein thromboses (DVT) and pulmonary emboli (PE). The reasons for this correlation are not fully understood. This retrospective, single-center review aimed to determine the risk factors for VTE in patients who underwent neurosurgical resection of brain tumors at Northwestern University from 1999 to 2010. Our cohort included 1148 patients, 158 (13.7%) of whom were diagnosed with DVT and 38 (3.3%) of whom were diagnosed with PE. A variety of clinical factors were studied to determine predictors of VTE, including sex, ethnicity, medical co-morbidities, surgical positioning, length of hospital stay, tumor location, and tumor histology. Use of post-operative anticoagulants and hemorrhagic complications were also investigated. A prior history of VTE was found to be highly predictive of post-operative DVT (odds ratio [OR]=7.6, p=0.01), as was the patient's sex (OR=14.2, p<0.001), ethnicity (OR=0.5, p=0.04), post-operative intensive care unit days (OR=0.2, p=0.003), and tumor histology (OR=-0.16, p=0.01). Contrary to reports in the literature, the data collected did not indicate that the administration of post-operative medical prophylaxis for VTE was significant in preventing their formation (OR=-0.14, p=0.76). Hemorrhagic complications were low (2.2%) and resultant neurologic deficit was lower still (0.7%). The study indicates that patients with high-grade primary brain tumors and metastatic lesions should receive aggressive preventative measures in the post-operative period. (Copyright © 2014 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Brain tumor; Deep vein thrombosis; Neurosurgery; Pulmonary embolism; Venous thromboembolism |
| المشرفين على المادة: | 0 (Anticoagulants) |
| تواريخ الأحداث: | Date Created: 20141224 Date Completed: 20160425 Latest Revision: 20220409 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.jocn.2014.10.003 |
| PMID: | 25533212 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2653 |
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| DOI: | 10.1016/j.jocn.2014.10.003 |