دورية أكاديمية
Comparative neuroanatomical distribution of the kappa and mu opioid receptors in guinea pig brain sections.
| العنوان: | Comparative neuroanatomical distribution of the kappa and mu opioid receptors in guinea pig brain sections. |
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| المؤلفون: | Lahti RA; CNS Diseases Research, Upjohn Company, Kalamazoo, MI 49001., Mickelson MM, Jodelis KS, McCall JM |
| المصدر: | European journal of pharmacology [Eur J Pharmacol] 1989 Aug 03; Vol. 166 (3), pp. 563-6. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print Cited Medium: Print ISSN: 0014-2999 (Print) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Science Original Publication: Amsterdam, North Holland Pub. Co. |
| مواضيع طبية MeSH: | Benzeneacetamides*, Brain/*metabolism , Receptors, Opioid/*metabolism, Animals ; Autoradiography ; Brain/anatomy & histology ; Guinea Pigs ; In Vitro Techniques ; Ligands ; Pyrrolidines/metabolism ; Receptors, Opioid, kappa ; Receptors, Opioid, mu |
| مستخلص: | The opiate family of receptors is believed to consist of the mu, delta, kappa and sigma subtypes. Autoradiographic studies have been conducted to define the distribution of the mu and delta receptors. However, due to the lack of a selective ligand definitive studies have not been reported for the kappa receptor. Recently such a ligand was discovered and characterized. Results are presented in which the distribution of kappa receptors in guinea pig brain slices were determined using autoradiographic techniques and its distribution compared to that of a typical mu ligand. The results demonstrate numerous differences between the two opioid systems. The kappa receptors predominate in the prefrontal cortex, the nucleus accumbens, and deep cortex; whereas the mu receptors have a more intense, broader and different distribution. |
| المشرفين على المادة: | 0 (Benzeneacetamides) 0 (Ligands) 0 (Pyrrolidines) 0 (Receptors, Opioid) 0 (Receptors, Opioid, kappa) 0 (Receptors, Opioid, mu) J5S4K6TKTG (U 69593) |
| تواريخ الأحداث: | Date Created: 19890803 Date Completed: 19891127 Latest Revision: 20190624 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/0014-2999(89)90377-4 |
| PMID: | 2553438 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0014-2999 |
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| DOI: | 10.1016/0014-2999(89)90377-4 |