دورية أكاديمية
Ghrelin's Role in the Hypothalamic-Pituitary-Adrenal Axis Stress Response: Implications for Mood Disorders.
| العنوان: | Ghrelin's Role in the Hypothalamic-Pituitary-Adrenal Axis Stress Response: Implications for Mood Disorders. |
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| المؤلفون: | Spencer SJ; School of Health Sciences and Health Innovations Research Institute, RMIT University, Bundoora, Melbourne, Victoria, Australia., Emmerzaal TL; Department of Anatomy, Radboud University Medical Centre, Nijmegen, The Netherlands., Kozicz T; Department of Anatomy, Radboud University Medical Centre, Nijmegen, The Netherlands; Hayward Genetics Center, Tulane University School of Medicine, New Orleans, Louisiana., Andrews ZB; Department of Physiology, School of Biomedical and Psychological Sciences, Monash University, Clayton, Melbourne, Victoria, Australia. Electronic address: Zane.Andrews@monash.edu. |
| المصدر: | Biological psychiatry [Biol Psychiatry] 2015 Jul 01; Vol. 78 (1), pp. 19-27. Date of Electronic Publication: 2014 Oct 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0213264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2402 (Electronic) Linking ISSN: 00063223 NLM ISO Abbreviation: Biol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Elsevier Original Publication: New York, Plenum Pub. Corp. |
| مواضيع طبية MeSH: | Ghrelin/*physiology , Hypothalamo-Hypophyseal System/*physiopathology , Mood Disorders/*physiopathology , Pituitary-Adrenal System/*physiopathology , Stress, Psychological/*physiopathology, Animals ; Feedback, Physiological ; Ghrelin/metabolism ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Mood Disorders/metabolism ; Pituitary-Adrenal System/metabolism ; Stress, Psychological/metabolism |
| مستخلص: | Ghrelin is a stomach hormone normally associated with feeding behavior and energy homeostasis. Recent studies highlight that ghrelin targets the brain to regulate a diverse number of functions, including learning, memory, motivation, stress responses, anxiety, and mood. In this review, we discuss recent animal and human studies showing that ghrelin regulates the hypothalamic-pituitary-adrenal axis and affects anxiety and mood disorders, such as depression and fear. We address the neural sites of action through which ghrelin regulates the hypothalamic-pituitary-adrenal axis and associated stress-induced behaviors, including the centrally projecting Edinger-Westphal nucleus, the hippocampus, amygdala, locus coeruleus, and the ventral tegmental area. Stressors modulate many behaviors associated with motivation, fear, anxiety, depression, and appetite; therefore, we assess the potential role for ghrelin as a stress feedback signal that regulates these associated behaviors. Finally, we briefly discuss important areas for future research that will help us move closer to potential ghrelin-based therapies to treat stress responses and related disorders. (Copyright © 2015 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Centrally projecting Edinger-Westphal nucleus; Depression; Ghrelin; Hypothalamic-pituitary-adrenal axis; Paraventricular nucleus of the hypothalamus; Pituitary; Stress |
| المشرفين على المادة: | 0 (Ghrelin) |
| تواريخ الأحداث: | Date Created: 20141224 Date Completed: 20160314 Latest Revision: 20220321 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.biopsych.2014.10.021 |
| PMID: | 25534754 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-2402 |
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| DOI: | 10.1016/j.biopsych.2014.10.021 |