دورية أكاديمية
أعرض في EDS

Interrogation of the Burkholderia pseudomallei genome to address differential virulence among isolates.

التفاصيل البيبلوغرافية
العنوان: Interrogation of the Burkholderia pseudomallei genome to address differential virulence among isolates.
المؤلفون: Challacombe JF; Los Alamos National Laboratory, Bioscience Division, Los Alamos, NM, United States of America., Stubben CJ; Los Alamos National Laboratory, Bioscience Division, Los Alamos, NM, United States of America., Klimko CP; US Army Medical Research Institute of Infectious Diseases, Bacteriology Division, Fort Detrick, MD, United States of America., Welkos SL; US Army Medical Research Institute of Infectious Diseases, Bacteriology Division, Fort Detrick, MD, United States of America., Kern SJ; US Army Medical Research Institute of Infectious Diseases, Biostatistics Division, Fort Detrick, MD, United States of America., Bozue JA; US Army Medical Research Institute of Infectious Diseases, Bacteriology Division, Fort Detrick, MD, United States of America., Worsham PL; US Army Medical Research Institute of Infectious Diseases, Bacteriology Division, Fort Detrick, MD, United States of America., Cote CK; US Army Medical Research Institute of Infectious Diseases, Bacteriology Division, Fort Detrick, MD, United States of America., Wolfe DN; Defense Threat Reduction Agency, Chemical and Biological Technologies Department, Fort Belvoir, VA, United States of America.
المصدر: PloS one [PLoS One] 2014 Dec 23; Vol. 9 (12), pp. e115951. Date of Electronic Publication: 2014 Dec 23 (Print Publication: 2014).
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Burkholderia pseudomallei/*genetics , Melioidosis/*microbiology, Animals ; Burkholderia pseudomallei/metabolism ; Burkholderia pseudomallei/pathogenicity ; Chromosomes, Bacterial ; Genome, Bacterial ; Humans ; Metabolic Networks and Pathways ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Virulence
مستخلص: Infection by the Gram-negative pathogen Burkholderia pseudomallei results in the disease melioidosis, acquired from the environment in parts of southeast Asia and northern Australia. Clinical symptoms of melioidosis range from acute (fever, pneumonia, septicemia, and localized infection) to chronic (abscesses in various organs and tissues, most commonly occurring in the lungs, liver, spleen, kidney, prostate and skeletal muscle), and persistent infections in humans are difficult to cure. Understanding the basic biology and genomics of B. pseudomallei is imperative for the development of new vaccines and therapeutic interventions. This formidable task is becoming more tractable due to the increasing number of B. pseudomallei genomes that are being sequenced and compared. Here, we compared three B. pseudomallei genomes, from strains MSHR668, K96243 and 1106a, to identify features that might explain why MSHR668 is more virulent than K96243 and 1106a in a mouse model of B. pseudomallei infection. Our analyses focused on metabolic, virulence and regulatory genes that were present in MSHR668 but absent from both K96243 and 1106a. We also noted features present in K96243 and 1106a but absent from MSHR668, and identified genomic differences that may contribute to variations in virulence noted among the three B. pseudomallei isolates. While this work contributes to our understanding of B. pseudomallei genomics, more detailed experiments are necessary to characterize the relevance of specific genomic features to B. pseudomallei metabolism and virulence. Functional analyses of metabolic networks, virulence and regulation shows promise for examining the effects of B. pseudomallei on host cell metabolism and will lay a foundation for future prediction of the virulence of emerging strains. Continued emphasis in this area will be critical for protection against melioidosis, as a better understanding of what constitutes a fully virulent Burkholderia isolate may provide for better diagnostic and medical countermeasure strategies.
التعليقات: Erratum in: PLoS One. 2015;10(3):e0122178. (PMID: 25806507)
References: Braz J Infect Dis. 2009 Feb;13(1):59-66. (PMID: 19578632)
BMC Biol. 2009;7:78. (PMID: 19922616)
Nucleic Acids Res. 2010 Jan;38(Database issue):D408-14. (PMID: 19843611)
Nucleic Acids Res. 2010 Jan;38(Database issue):D473-9. (PMID: 19850718)
Nucleic Acids Res. 2010 Jan;38(Database issue):D111-8. (PMID: 19884135)
Am J Trop Med Hyg. 2010 Jan;82(1):88-94. (PMID: 20065001)
PLoS Pathog. 2010 Apr;6(4):e1000845. (PMID: 20368977)
Nat Rev Microbiol. 2010 Jun;8(6):401-12. (PMID: 20453875)
Annu Rev Microbiol. 2010;64:495-517. (PMID: 20528691)
Nucleic Acids Res. 2014 Jan;42(Database issue):D191-8. (PMID: 24253303)
PLoS One. 2014;9(3):e91682. (PMID: 24618705)
Acta Trop. 2000 Feb 5;74(2-3):153-8. (PMID: 10674644)
Infect Immun. 2000 Apr;68(4):2034-42. (PMID: 10722599)
Gene. 2000 Aug 22;254(1-2):129-37. (PMID: 10974543)
Int J Antimicrob Agents. 2001 Feb;17(2):109-13. (PMID: 11165114)
Am J Trop Med Hyg. 2001 Sep;65(3):177-9. (PMID: 11561699)
Bioinformatics. 2002;18 Suppl 1:S225-32. (PMID: 12169551)
Lancet. 2003 May 17;361(9370):1715-22. (PMID: 12767750)
Eur Respir J. 2003 Sep;22(3):542-50. (PMID: 14516149)
Genome Res. 2004 Jul;14(7):1394-403. (PMID: 15231754)
Am J Trop Med Hyg. 2004 Sep;71(3):360-2. (PMID: 15381819)
Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14240-5. (PMID: 15377794)
Chest. 1975 Aug;68(2):261-3. (PMID: 1149556)
Annu Rev Genet. 1985;19:355-87. (PMID: 3936407)
J Bacteriol. 1990 Sep;172(9):4758-65. (PMID: 2118500)
J Mol Biol. 1990 Oct 5;215(3):403-10. (PMID: 2231712)
Jpn J Med Sci Biol. 1991 Apr;44(2):63-74. (PMID: 1720182)
Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11978-82. (PMID: 1465428)
PLoS Negl Trop Dis. 2010;4(11):e900. (PMID: 21152057)
BMC Genomics. 2010;11:672. (PMID: 21110886)
Appl Environ Microbiol. 2011 Jan;77(2):532-6. (PMID: 21075883)
Trends Microbiol. 2011 Mar;19(3):128-35. (PMID: 21215638)
Br Med Bull. 2011;99:125-39. (PMID: 21558159)
Appl Environ Microbiol. 2011 Sep;77(18):6486-94. (PMID: 21803915)
FEBS Lett. 2011 Oct 3;585(19):2929-34. (PMID: 21864534)
Nucleic Acids Res. 2012 Jan;40(Database issue):D641-5. (PMID: 22067448)
FEMS Microbiol Rev. 2012 Mar;36(2):435-62. (PMID: 22092350)
Microbes Infect. 2012 Apr;14(4):335-40. (PMID: 22172334)
Microbiol Immunol. 2012 May;56(5):281-94. (PMID: 22385268)
Environ Microbiol. 2012 Aug;14(8):2058-70. (PMID: 22176696)
BMC Genomics. 2012;13:328. (PMID: 22823543)
Nucleic Acids Res. 2000 Jan 1;28(1):27-30. (PMID: 10592173)
Mol Microbiol. 1999 Apr;32(2):223-32. (PMID: 10231480)
Genome Res. 2004 Nov;14(11):2273-8. (PMID: 15479949)
J Clin Microbiol. 2004 Dec;42(12):5477-83. (PMID: 15583269)
J Antimicrob Chemother. 2004 Dec;54(6):1134-8. (PMID: 15509614)
J Clin Microbiol. 2005 Feb;43(2):970-2. (PMID: 15695721)
Clin Microbiol Rev. 2005 Apr;18(2):383-416. (PMID: 15831829)
Nucleic Acids Res. 2005;33(10):3125-32. (PMID: 15933207)
Environ Microbiol. 2005 Nov;7(11):1673-85. (PMID: 16232283)
Nucleic Acids Res. 2006 Jan 1;34(Database issue):D344-8. (PMID: 16381883)
Microb Pathog. 2006 Apr;40(4):184-9. (PMID: 16524693)
Infect Immun. 2006 Oct;74(10):5465-76. (PMID: 16988221)
J Bacteriol. 2006 Dec;188(23):8178-88. (PMID: 16997946)
Microbiol Mol Biol Rev. 2006 Dec;70(4):939-1031. (PMID: 17158705)
Nucleic Acids Res. 2007;35(5):1432-40. (PMID: 17284458)
J Bacteriol. 2007 Dec;189(24):9044-9. (PMID: 17933898)
FEMS Microbiol Rev. 2008 Jan;32(1):38-55. (PMID: 18070067)
Genome Biol. 2007;8(7):R150. (PMID: 17663773)
Microb Pathog. 2008 Mar;44(3):238-45. (PMID: 18022342)
BMC Genomics. 2008;9:75. (PMID: 18261238)
BMC Genomics. 2008;9:190. (PMID: 18439288)
PLoS Pathog. 2008 Oct;4(10):e1000178. (PMID: 18927621)
BMC Genomics. 2008;9:566. (PMID: 19038032)
Biosci Biotechnol Biochem. 2009 Feb;73(2):245-59. (PMID: 19202299)
PLoS One. 2012;7(10):e48053. (PMID: 23110173)
Cell Microbiol. 2013 Jun;15(6):882-90. (PMID: 23490329)
Cell Microbiol. 2013 Jul;15(7):1079-87. (PMID: 23521858)
FEMS Microbiol Rev. 2013 Sep;37(5):634-63. (PMID: 23790204)
PLoS Genet. 2013;9(9):e1003795. (PMID: 24068961)
Proc Int Conf Intell Syst Mol Biol. 1997;5:333-9. (PMID: 9322058)
Mol Microbiol. 1998 Dec;30(5):1081-100. (PMID: 9988483)
تواريخ الأحداث: Date Created: 20141224 Date Completed: 20151201 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4275268
DOI: 10.1371/journal.pone.0115951
PMID: 25536074
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0115951