دورية أكاديمية
An exclusively based parenteral fish-oil emulsion reverses cholestasis.
| العنوان: | An exclusively based parenteral fish-oil emulsion reverses cholestasis. |
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| المؤلفون: | Triana Junco M; Neonatology Department, La Paz University Hospital, Madrid, España.. mtrianaj@hotmail.com., García Vázquez N; Pharmacy Department, La Paz University Hospital, Madrid, España.. mnatalia.garcia@salud.madrid.org., Zozaya C; Neonatology Department, La Paz University Hospital, Madrid, España.. zozaia6@hotmail.com., Ybarra Zabala M; Neonatology Department, La Paz University Hospital, Madrid, España.. martamenciaybarra@gmail.com., Abrams S; Baylor College of Medicine, Houston, Texas.. sabrams@bcm.edu., García de Lorenzo A; Intensive Care Unit, La Paz University Hospital, Madrid, España.. agdl@telefonica.net., Sáenz de Pipaón Marcos M; Neonatology Department, La Paz University Hospital, Madrid, España.. miguel.saenz@salud.madrid.org. |
| المصدر: | Nutricion hospitalaria [Nutr Hosp] 2014 Oct 25; Vol. 31 (1), pp. 514-6. Date of Electronic Publication: 2014 Oct 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Grupo Aran Country of Publication: Spain NLM ID: 9100365 Publication Model: Electronic Cited Medium: Internet ISSN: 1699-5198 (Electronic) Linking ISSN: 02121611 NLM ISO Abbreviation: Nutr Hosp Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Madrid : Grupo Aran Original Publication: Madrid : Jarpyo Editores, |
| مواضيع طبية MeSH: | Cholestasis/*drug therapy , Fat Emulsions, Intravenous/*therapeutic use , Fish Oils/*therapeutic use, Fat Emulsions, Intravenous/administration & dosage ; Fatty Acids, Omega-3/administration & dosage ; Fatty Acids, Omega-3/therapeutic use ; Fish Oils/administration & dosage ; Gastroschisis/therapy ; Humans ; Infant, Newborn ; Male ; Parenteral Nutrition ; Soybean Oil/administration & dosage ; Soybean Oil/therapeutic use ; Triglycerides/blood |
| مستخلص: | Prolonged parenteral nutrition (PN) leads to liver damage. Recent interest has focused on the lipid component of PN. A lipid emulsion based on w-3 fatty acids decrease conjugated bilirubin. A mixed lipid emulsion derived from soybean, coconut, olive, and fish oils reverses jaundice. Here we report the reversal of cholestasis and the improvement of enteral feeding tolerance in 1 infant with intestinal failure-associated liver disease. Treatment involved the substitution of a mixed lipid emulsion with one containing primarily omega-3 fatty acids during 37 days. Growth and biochemical tests of liver function improved significantly. This suggests that fat emulsions made from fish oils may be more effective means of treating this condition compared with an intravenous lipid emulsion containing soybean oil, medium -chain triglycerides, olive oil, and fish oil. (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.) |
| فهرسة مساهمة: | Local Abstract: [Publisher, Spanish; Castilian] La nutrición parenteral prolongada produce daño hepático. Recientemente se ha comunicado el efecto de las emulsiones lipídicas intravenosas basadas exclusivamente en ácidos grasos omega-3 en la resolución de la colestasis. Lo mismo se ha observado con el uso de emulsiones lipídicas mixta derivadas del aceite de soja, coco, oliva y pescado. Comunicamos la desaparición de colestasis y mejoría de la tolerancia enteral en un niño con enfermedad hepática asociada a nutrición parenteral. El tratamiento consistió en sustituir una emulsión lipídica mixta por otra que contenía de forma exclusiva aceite de pescado durante 37 días. El crecimiento y los datos bioquímicos de función hepática mejoraron de forma significativa. Este caso sugiere que emulsiones lipídicas intravenosas a partir de aceite de pescado pueden ser mas eficaces para tratar la colestasis si se comparan con emulsiones mixtas. |
| المشرفين على المادة: | 0 (Fat Emulsions, Intravenous) 0 (Fatty Acids, Omega-3) 0 (Fish Oils) 0 (Triglycerides) 8001-22-7 (Soybean Oil) |
| تواريخ الأحداث: | Date Created: 20150107 Date Completed: 20170127 Latest Revision: 20170127 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3305/nh.2015.31.1.8284 |
| PMID: | 25561149 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1699-5198 |
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| DOI: | 10.3305/nh.2015.31.1.8284 |