دورية أكاديمية
[The associations of ulcerative colitis with vascular endothelial growth factor (-2578C/A) and (+936C/T) single nucleotide polymorphisms].
| العنوان: | [The associations of ulcerative colitis with vascular endothelial growth factor (-2578C/A) and (+936C/T) single nucleotide polymorphisms]. |
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| المؤلفون: | Yu L, Xia S, Zheng B, Guo M, Lin X, Lin X, Jiang L, Ding R, Jiang Y; Department of Gastroenterology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Email: wzjiangyi@yeah.net. |
| المصدر: | Zhonghua nei ke za zhi [Zhonghua Nei Ke Za Zhi] 2014 Oct; Vol. 53 (10), pp. 799-803. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua yi xue hui Country of Publication: China NLM ID: 16210490R Publication Model: Print Cited Medium: Print ISSN: 0578-1426 (Print) Linking ISSN: 05781426 NLM ISO Abbreviation: Zhonghua Nei Ke Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Beijing : Zhonghua yi xue hui Nei ke xue hui |
| مواضيع طبية MeSH: | Colitis, Ulcerative/*genetics , Vascular Endothelial Growth Factor A/*genetics, Alleles ; Genetic Predisposition to Disease ; Genotype ; Humans ; Mutation ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide |
| مستخلص: | Objective: To investigate the association of (-2578C/A) and (+936C/T) single nucleotide polymorphism(SNPs) of vascular endothelial growth factor (VEGF) gene with the susceptibility to ulcerative colitis (UC). Methods: A total of 373 UC patients and 503 healthy controls were recruited. The (-2578C/A) and (+936C/T) polymorphism of VEGF gene were detected using a mini-sequencing technique. Results: By an unconditional logistic regression analysis, the frequencies of the mutant allele T and genotype CT+TT of VEGF gene (+936C/T) were significantly decreased in patients with severe UC compared to the controls (10.4% vs 19.3%, OR = 0.487, 95%CI 0.248-0.954, P = 0.036; 18.8% vs 33.8%, OR = 0.452, 95%CI 0.214-0.955, P = 0.037, respectively). Moreover, patients with severe UC had significant lower rates of mutant allele T and genotype CT+TT compared with patients with mild and moderate UC (10.4% vs 20.5%, OR = 0.452, 95%CI 0.229-0.894, P = 0.022; 18.8% vs 36.9%, OR = 0.394, 95%CI 0.185-0.842, P = 0.016, respectively). The frequencies of mutant allele A and genotype CA+AA of VEGF (-2578C/A) gene were not statistically different between UC patients and the controls. Moreover, they were not significantly associated with the clinicopathologic features in UC patients. Conclusions: The mutation of VEGF (+936C/T) gene is correlated with the severity of UC. However, the polymorphism of VEGF (-2578C/A) gene is not significantly related to the susceptibility to UC. |
| المشرفين على المادة: | 0 (Vascular Endothelial Growth Factor A) |
| تواريخ الأحداث: | Date Created: 20150109 Date Completed: 20150520 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| PMID: | 25567152 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0578-1426 |
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