دورية أكاديمية
أعرض في EDS

Subacute toxicity of titanium dioxide (TiO2) nanoparticles in male rats: emotional behavior and pathophysiological examination.

التفاصيل البيبلوغرافية
العنوان: Subacute toxicity of titanium dioxide (TiO2) nanoparticles in male rats: emotional behavior and pathophysiological examination.
المؤلفون: Younes NR; Laboratory of Integrated Physiology, Faculty of Science of Bizerte, Carthage University, 7021, Jarzouna, Tunisia., Amara S, Mrad I, Ben-Slama I, Jeljeli M, Omri K, El Ghoul J, El Mir L, Rhouma KB, Abdelmelek H, Sakly M
المصدر: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2015 Jun; Vol. 22 (11), pp. 8728-37. Date of Electronic Publication: 2015 Jan 10.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
أسماء مطبوعة: Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
مواضيع طبية MeSH: Nanoparticles/*toxicity , Titanium/*toxicity, Alanine Transaminase/blood ; Animals ; Anxiety/chemically induced ; Aspartate Aminotransferases/blood ; Behavior, Animal/drug effects ; Brain/anatomy & histology ; Brain/drug effects ; Brain/metabolism ; Kidney/anatomy & histology ; Kidney/drug effects ; L-Lactate Dehydrogenase/blood ; Liver/anatomy & histology ; Liver/drug effects ; Liver/metabolism ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Male ; Organ Size/drug effects ; Platelet Count ; Rats, Wistar ; Thymus Gland/drug effects ; Thymus Gland/pathology ; Titanium/pharmacokinetics ; Toxicity Tests, Subacute
مستخلص: Titanium dioxide nanoparticles (TiO2 NPs) have a wide range of applications in many fields (paint, industry, medicine, additives in food colorants, and nutritional products). Over the past decade research, TiO2 NPs have been focused on the potential toxic effects of these useful materials. In the present study, we investigated the effects of subacute exposure to TiO2 NPs on emotional behavior in adult Wistar rats, the biochemical parameters, and the histology of organs. Animals were injected intraperitoneally (ip) with TiO2 NPs (20 mg/kg body weight) every 2 days for 20 days. The elevated plus-maze test showed that subacute TiO2 NPs treatment increased significantly the anxious index (AI) compared to control group. The toxicological parameters were assessed 24 h and 14 days after the last injection of TiO2 NPs. Subacute exposure to nanoparticles increased the AST/ALT enzyme ratio and LDH activity. However, the blood cell count remained unchanged, except the platelet count increase. Histological examination showed a little inflammation overall. Moreover, our results provide strong evidence that the TiO2 NPs can induce the liver pathological changes of rats. The intraperitoneal injection of TiO2 NPs increased the accumulation of titanium in the liver, lung, and the brain. The results suggest that TiO2 NPs could alter the neurobehavioral performance of adult Wistar rats and promotes alterations in hepatic tissues.
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المشرفين على المادة: 15FIX9V2JP (titanium dioxide)
D1JT611TNE (Titanium)
EC 1.1.1.27 (L-Lactate Dehydrogenase)
EC 2.6.1.1 (Aspartate Aminotransferases)
EC 2.6.1.2 (Alanine Transaminase)
تواريخ الأحداث: Date Created: 20150110 Date Completed: 20150812 Latest Revision: 20181202
رمز التحديث: 20231215
DOI: 10.1007/s11356-014-4002-5
PMID: 25572266
قاعدة البيانات: MEDLINE
الوصف
تدمد:1614-7499
DOI:10.1007/s11356-014-4002-5