دورية أكاديمية
أعرض في EDS

Prospects of molybdenum and rhenium octahedral cluster complexes as X-ray contrast agents.

التفاصيل البيبلوغرافية
العنوان: Prospects of molybdenum and rhenium octahedral cluster complexes as X-ray contrast agents.
المؤلفون: Krasilnikova AA; Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation., Shestopalov MA; Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation; Nikolaev Institute of Inorganic Chemistry of Siberian Branch of the Russian Academy of Sciences, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russian Federation; Scientific Institute of Clinical and Experimental Lymphology, 2 Timakova Str., Novosibirsk 630060, Russian Federation. Electronic address: shtopy@niic.nsc.ru., Brylev KA; Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation; Nikolaev Institute of Inorganic Chemistry of Siberian Branch of the Russian Academy of Sciences, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russian Federation., Kirilova IA; Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan, 17 Frunze Str., Novosibirsk 630091, Russian Federation., Khripko OP; The State Research Center of Virology and Biotechnology VECTOR, Koltsovo 630559, Russian Federation., Zubareva KE; Scientific Institute of Clinical and Experimental Lymphology, 2 Timakova Str., Novosibirsk 630060, Russian Federation; The State Research Center of Virology and Biotechnology VECTOR, Koltsovo 630559, Russian Federation., Khripko YI; The State Research Center of Virology and Biotechnology VECTOR, Koltsovo 630559, Russian Federation., Podorognaya VT; Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan, 17 Frunze Str., Novosibirsk 630091, Russian Federation., Shestopalova LV; Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation., Fedorov VE; Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation; Nikolaev Institute of Inorganic Chemistry of Siberian Branch of the Russian Academy of Sciences, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russian Federation., Mironov YV; Novosibirsk State University, 2 Pirogova Str., Novosibirsk 630090, Russian Federation; Nikolaev Institute of Inorganic Chemistry of Siberian Branch of the Russian Academy of Sciences, 3, Acad. Lavrentiev Ave., Novosibirsk 630090, Russian Federation.
المصدر: Journal of inorganic biochemistry [J Inorg Biochem] 2015 Mar; Vol. 144, pp. 13-7. Date of Electronic Publication: 2014 Dec 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7905788 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3344 (Electronic) Linking ISSN: 01620134 NLM ISO Abbreviation: J Inorg Biochem Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, Elsevier.
مواضيع طبية MeSH: Contrast Media*/chemistry , Contrast Media*/pharmacokinetics , Contrast Media*/toxicity , Coordination Complexes*/chemistry , Coordination Complexes*/pharmacokinetics , Coordination Complexes*/toxicity , Molybdenum* , Rhenium*, Animals ; Cell Line, Tumor ; Humans ; Rats ; Rats, Wistar/physiology ; Renal Elimination ; Tomography, X-Ray Computed
مستخلص: Investigation of new X-ray contrast media for radiography is an important field of science since discovering of X-rays in 1895. Despite the wide diversity of available X-ray contrast media the toxicity, especially nephrotoxicity, is still a big problem to be solved. The octahedral metal-cluster complexes of the general formula [{M6Q8}L6] can be considered as quite promising candidates for the role of new radiocontrast media due to the high local concentration of heavy elements, high tuning ability of ligand environment and low toxicity. To exemplify this, the X-ray computed tomography experiments for the first time were carried out on some octahedral cluster complexes of molybdenum and rhenium. Based on the obtained data it was proposed to investigate the toxicological proprieties of cluster complex Na2H8[{Re6Se8}(P(CH2CH2CONH2)(CH2CH2COO)2)6]. Observed low cytotoxic and acute toxic effects along with rapid renal excretion of the cluster complex evidence its perspective as an X-ray contrast media for radiography.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Octahedral metal clusters; X-ray computed tomography; X-ray contrast media
المشرفين على المادة: 0 (Contrast Media)
0 (Coordination Complexes)
7440-15-5 (Rhenium)
81AH48963U (Molybdenum)
تواريخ الأحداث: Date Created: 20150110 Date Completed: 20150821 Latest Revision: 20150119
رمز التحديث: 20240628
DOI: 10.1016/j.jinorgbio.2014.12.016
PMID: 25575304
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3344
DOI:10.1016/j.jinorgbio.2014.12.016