دورية أكاديمية
أعرض في EDS

Correlation between vascular endothelial growth factor expression and presence of lymph node metastasis in advanced squamous cell carcinoma of the larynx.

التفاصيل البيبلوغرافية
العنوان: Correlation between vascular endothelial growth factor expression and presence of lymph node metastasis in advanced squamous cell carcinoma of the larynx.
المؤلفون: Bonhin RG; Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Electronic address: bonhin@yahoo.com., Rocha VB; Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil., Carvalho GM; Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil., Guimarães AC; Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil., Crespo AN; Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil., Chone CT; Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil., Amstalden EM; Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil.
المصدر: Brazilian journal of otorhinolaryngology [Braz J Otorhinolaryngol] 2015 Jan-Feb; Vol. 81 (1), pp. 58-62. Date of Electronic Publication: 2014 Nov 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: E.N.T. Brazilian Society Country of Publication: Brazil NLM ID: 101207337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1808-8686 (Electronic) Linking ISSN: 18088686 NLM ISO Abbreviation: Braz J Otorhinolaryngol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: São Paulo, SP, Brasil : E.N.T. Brazilian Society
مواضيع طبية MeSH: Carcinoma, Squamous Cell/*pathology , Carcinoma, Squamous Cell/*secondary , Laryngeal Neoplasms/*pathology , Vascular Endothelial Growth Factor A/*blood, Biomarkers, Tumor/blood ; Carcinoma, Squamous Cell/blood ; Humans ; Immunohistochemistry ; Laryngeal Neoplasms/blood ; Lymphatic Metastasis ; Neoplasm Staging ; Retrospective Studies
مستخلص: Introduction: Squamous cell carcinoma is the most common neoplasm of the larynx, and its evolution depends on tumor staging. Vascular endothelial growth factor is a marker of angiogenesis, and its expression may be related to increased tumor aggressiveness, as evidenced by the presence of cervical lymphatic metastases.
Objectives: To evaluate the expression of the vascular endothelial growth factor marker in non-glottic advanced squamous cell carcinoma of the larynx (T3/T4) and correlate it with the presence of cervical lymph node metastases.
Methods: Retrospective clinical study and immunohistochemical analysis of vascular endothelial growth factor through the German scale of immunoreactivity in products of non-glottic squamous cell carcinomas.
Results: This study analyzed 15 cases of advanced non-glottic laryngeal tumors (T3/T4), four of which exhibited cervical lymphatic metastases. There was no correlation between vascular endothelial growth factor expression and the presence of cervical metastases.
Conclusion: Although vascular endothelial growth factor was expressed in a few cases, there was no correlation with the spread of cervical lymph metastases.
(Copyright © 2014 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.)
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فهرسة مساهمة: Keywords: Carcinoma epidermoide de laringe; Cervical lymphatic metastases; Immunohistochemistry; Imunohistoquímica; Metástase; Squamous cell carcinoma of larynx; VEGF
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (Vascular Endothelial Growth Factor A)
تواريخ الأحداث: Date Created: 20150118 Date Completed: 20160516 Latest Revision: 20220910
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9452213
DOI: 10.1016/j.bjorl.2014.08.016
PMID: 25595850
قاعدة البيانات: MEDLINE
الوصف
تدمد:1808-8686
DOI:10.1016/j.bjorl.2014.08.016