دورية أكاديمية
أعرض في EDS

Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive-Compulsive Disorder Patients.

التفاصيل البيبلوغرافية
العنوان: Visuospatial Memory Improvement after Gamma Ventral Capsulotomy in Treatment Refractory Obsessive-Compulsive Disorder Patients.
المؤلفون: Batistuzzo MC; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil., Hoexter MQ; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil., Taub A; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil., Gentil AF; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil., Cesar RC; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil., Joaquim MA; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil., D'Alcante CC; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil., McLaughlin NC; Department of Psychiatry and Behavioral Sciences, Butler Hospital and Brown Medical School, Providence, RI, USA., Canteras MM; Institute of Neurological Radiosurgery-Hospital Santa Paula, São Paulo, Brazil., Shavitt RG; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil., Savage CR; Center for Health Behavior Neuroscience, University of Kansas Medical Center, Kansas City, KS, USA., Greenberg BD; Department of Psychiatry and Behavioral Sciences, Butler Hospital and Brown Medical School, Providence, RI, USA., Norén G; Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, RI, USA., Miguel EC; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil., Lopes AC; Department & Institute of Psychiatry, School of Medicine, University of São Paulo, São Paulo, Brazil.
المصدر: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2015 Jul; Vol. 40 (8), pp. 1837-45. Date of Electronic Publication: 2015 Feb 03.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-634X (Electronic) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : London : Nature Publishing Group
Original Publication: [New York, NY] : Elsevier, [c1987-
مواضيع طبية MeSH: Internal Capsule/*surgery , Memory Disorders/*etiology , Memory Disorders/*surgery , Obsessive-Compulsive Disorder/*complications , Radiosurgery/*methods , Space Perception/*physiology, Adult ; Double-Blind Method ; Executive Function ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Obsessive-Compulsive Disorder/surgery ; Psychiatric Status Rating Scales ; Statistics, Nonparametric ; Treatment Outcome ; Young Adult
مستخلص: Gamma ventral capsulotomy (GVC) radiosurgery is intended to minimize side effects while maintaining the efficacy of traditional thermocoagulation techniques for the treatment of refractory obsessive-compulsive disorder (OCD). Neuropsychological outcomes are not clear based on previous studies and, therefore, we investigated the effects of GVC on cognitive and motor performance. A double-blind, randomized controlled trial (RCT) was conducted with 16 refractory OCD patients allocated to active treatment (n=8) and sham (n=8) groups. A comprehensive neuropsychological evaluation including intellectual functioning, attention, verbal and visuospatial learning and memory, visuospatial perception, inhibitory control, cognitive flexibility, and motor functioning was applied at baseline and one year after the procedure. Secondary analysis included all operated patients: eight from the active group, four from the sham group who were submitted to surgery after blind was broken, and five patients from a previous open pilot study (n=5), totaling 17 patients. In the RCT, visuospatial memory (VSM) performance significantly improved in the active group after GVC (p=0.008), and remained stable in the sham group. Considering all patients operated, there was no decline in cognitive or motor functioning after one year of follow-up. Our initial results after 1 year of follow-up suggests that GVC not only is a safe procedure in terms of neuropsychological functioning but in fact may actually improve certain neuropsychological domains, particularly VSM performance, in treatment refractory OCD patients.
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سلسلة جزيئية: ClinicalTrials.gov NCT01004302
تواريخ الأحداث: Date Created: 20150204 Date Completed: 20160308 Latest Revision: 20240325
رمز التحديث: 20240325
مُعرف محوري في PubMed: PMC4839507
DOI: 10.1038/npp.2015.33
PMID: 25645373
قاعدة البيانات: MEDLINE
الوصف
تدمد:1740-634X
DOI:10.1038/npp.2015.33