دورية أكاديمية
Evaluation and management of hypersensitivity reactions to chemotherapy agents.
| العنوان: | Evaluation and management of hypersensitivity reactions to chemotherapy agents. |
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| المؤلفون: | Tham EH; University Children's Medical Institute, National University Hospital, Singapore, Singapore Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Cheng YK; Department of Allergy, Arthritis & Rheumatism Clinic, Gleneagles Medical Centre, Singapore, Singapore., Tay MH; Oncocare Clinic, Gleneagles Medical Centre, Singapore, Singapore., Alcasabas AP; University Children's Medical Institute, National University Hospital, Singapore, Singapore Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Shek LP; University Children's Medical Institute, National University Hospital, Singapore, Singapore Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. |
| المصدر: | Postgraduate medical journal [Postgrad Med J] 2015 Mar; Vol. 91 (1073), pp. 145-50. Date of Electronic Publication: 2015 Feb 06. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0234135 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0756 (Electronic) Linking ISSN: 00325473 NLM ISO Abbreviation: Postgrad Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Oxford : Oxford University Press Original Publication: London, Blackwell. |
| مواضيع طبية MeSH: | Antineoplastic Agents/*adverse effects , Bridged-Ring Compounds/*immunology , Cisplatin/*immunology , Drug Hypersensitivity/*diagnosis , Taxoids/*immunology, Antineoplastic Agents/immunology ; Bridged-Ring Compounds/adverse effects ; Cisplatin/adverse effects ; Desensitization, Immunologic ; Dose-Response Relationship, Immunologic ; Drug Hypersensitivity/immunology ; Humans ; Referral and Consultation ; Risk Factors ; Skin Tests ; Taxoids/adverse effects ; Treatment Outcome |
| مستخلص: | Hypersensitivity reactions to chemotherapy drugs pose significant difficulties in management, especially when no suitable alternative is available or acceptable and delay in continuation of treatment may be life-threatening. Such reactions may be IgE- or non-IgE-mediated and have varied manifestations. Timely recognition and treatment of life-threatening hypersensitivity reactions are essential. Identification of patients at high risk of developing hypersensitivity reactions allows risk stratification to guide clinical decision-making. Skin testing for carboplatin hypersensitivity has good predictive value but is not yet established for oxaliplatin and taxane hypersensitivity. Rapid desensitisation may be considered if no suitable alternative drug is available. Available protocols have shown good safety and efficacy but must be performed in an appropriate setting with adequate monitoring. There are many avenues for research into the utility of skin testing for other chemotherapy agents as well as in vitro tests. (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.) |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Bridged-Ring Compounds) 0 (Taxoids) 1605-68-1 (taxane) Q20Q21Q62J (Cisplatin) |
| تواريخ الأحداث: | Date Created: 20150210 Date Completed: 20151230 Latest Revision: 20161125 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1136/postgradmedj-2014-132686 |
| PMID: | 25659930 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1469-0756 |
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| DOI: | 10.1136/postgradmedj-2014-132686 |